Merck
所有图片(1)

47729

Sigma-Aldrich

N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸

BioXtra, ≥99.0% (TLC)

别名:
fMLP(用词错误,但已被广泛使用), N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸, fMLF, 趋化肽
Empirical Formula (Hill Notation):
C21H31N3O5S
CAS号:
分子量:
437.55
Beilstein:
2315783
MDL编号:
PubChem化学物质编号:

产品线

BioXtra

测定

≥99.0% (TLC)

形式

powder

颜色

white

溶解性

DMF: 50 mg/mL, clear, colorless

application(s)

cell analysis

储存温度

2-8°C

SMILES string

CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1

InChI key

PRQROPMIIGLWRP-BZSNNMDCSA-N

Gene Information

human ... FPR1(2357)

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Amino Acid Sequence

NFor-Met-Leu-Phe

生化/生理作用

N-甲酰基-Met-Leu-Phe是一种有效的趋化肽和甲酰肽受体(FPR)激动剂,可诱导巨噬细胞的代谢爆发,伴随呼吸四氯、溶酶体酶分泌和超氧阴离子产生的增加。
有效的趋化肽。诱导巨噬细胞的代谢爆发,并伴随着呼吸速率的增加、溶酶体酶的分泌以及超氧阴离子的产生。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

更多文件

Quotes and Ordering

C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Astrid L Voskamp et al.
The journal of allergy and clinical immunology. In practice, 3(2), 192-199 (2015-02-03)
Allergic bronchopulmonary aspergillosis (ABPA) often presents with persistently uncontrolled asthma despite the use of corticosteroids and antifungal therapy. Omalizumab is a humanized anti-IgE monoclonal antibody currently used to treat severe asthma. The aim was to assess the clinical and immunologic
J James B Edelman et al.
Shock (Augusta, Ga.), 39(2), 149-154 (2013-01-18)
Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without
Karama Makni-Maalej et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
Isaac M Chiu et al.
Nature, 501(7465), 52-57 (2013-08-24)
Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviours. Bacterial infections produce pain by unknown molecular mechanisms, although they are presumed to be secondary to immune

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