Merck
所有图片(1)

文件

88908

Sigma-Aldrich

Methoxypolyethylene glycol 5,000 propionic acid

≥80%

所有图片(1)
别名:
O-(2-Carboxyethyl)-O′-methylpolyethylene glycol 5,000, mono-Methyl polyethylene glycol 5′000 propionic acid
MDL编号:
MFCD05665436
NACRES:
NA.25

质量水平

100

检测方案

≥80%

形式

lumps

Ω端

carboxylic acid

α端

methoxy

储存温度

−20°C

相关类别

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此商品
8596970718920401
Methoxypolyethylene glycol 5,000 propionic acid ≥80%

Sigma-Aldrich

88908

Methoxypolyethylene glycol 5,000 propionic acid

Methoxypolyethylene glycol 5,000 propionic acid N-succinimidyl ester ≥80%

Supelco

85969

甲氧基聚乙二醇 5,000 丙酸 N-琥珀酰亚胺基酯

Methoxypolyethylene glycol 5,000 acetic acid ≥80%

Sigma-Aldrich

70718

Methoxypolyethylene glycol 5,000 acetic acid

Methoxypolyethylene glycol 1,000 propionic acid

Sigma-Aldrich

920401

Methoxypolyethylene glycol 1,000 propionic acid

form

lumps

form

solid

form

powder

form

solid

Ω-end

carboxylic acid

Ω-end

-

Ω-end

carboxylic acid

Ω-end

(Propionic acid)

α-end

methoxy

α-end

-

α-end

methoxy

α-end

methoxy

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

应用

Methoxypolyethylene glycol 5,000 propionic acid (M-SPA-PEG 5000) is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum half-life of proteins and enzymes.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Y Tan et al.
Protein expression and purification, 12(1), 45-52 (1998-03-14)
Recombinant methioninase (rMETase) is a homotetrameric pyridoxal 5'-phosphate enzyme of 172-kda molecular mass derived from Pseudomonas putida and cloned in Escherichia coli. rMETase has been found previously to be an effective, anti-tumor agent in vitro and in vivo. The enzyme
Yihong Huang et al.
International journal of hematology, 92(4), 609-616 (2010-10-19)
We designed to determine whether pretreatment of allografts with methoxypolyethylene glycol-succinimidyl-propionic acid ester (mPEG-SPA) and an anti-OX40L monoclonal antibody (McAb) can relieve acute graft-versus-host disease in allogeneic bone marrow transplantation recipients. Responder splenocytes from C57BL/6 donor mice were incubated with
Amanda J Bradley et al.
Biochimica et biophysica acta, 1561(2), 147-158 (2002-05-09)
Immunocamouflaged red blood cells (RBC) are produced by cell surface derivatization with methoxypolyethylene glycol (mPEG). These immunologically attenuated cells may reduce the risk of allosensitization in chronically transfused patients. To characterize the effects of differing linker chemistries and polymer lengths
Chun Zhang et al.
PloS one, 7(6), e39659-e39659 (2012-06-30)
Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction of its immunogenicity may be the largest obstacle to its chronic use. In this study, canine uricase was modified with 5 kDa mPEG-SPA and the impact of large aggregated

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