所有图片(1)

91077C

SAFC

重组人胰岛素

for research or for further manufacturing use, dry powder

别名:
重组胰岛素, 胰岛素 钠盐 人
CAS号:
EC 号:
MDL编号:
NACRES:
NA.77

质量水平

300

无菌性

sterile; 0.2 μm filtered

形式

dry powder

效能

≥27.5 units per mg

technique(s)

cell culture | mammalian: suitable

杂质

≤1.0 EU/mL endotoxin

溶解性

water: 10 mg/mL (pH 2.0—2.5)

UniProt登记号

运输

ambient

储存温度

−20°C

InChI key

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Gene Information

human ... INS(3630)

正在寻找类似产品? Visit 产品对比指南

一般描述

重组人胰岛素(rHu)在功能和结构上与天然人序列相同。由两个多肽链组成的激素,rHu 胰岛素的 A 链(21 个氨基酸)和 B 链(30 个氨基酸)通过半胱氨酸残基之间的二硫键共价连接。这种经基因工程改造的人胰岛素是全序列分子,通过重组 DNA 技术在面包酵母中生产。

应用

无血清培养基补充剂(如胰岛素)对于常用哺乳动物细胞系的长期生长至关重要。当培养基中缺少胰岛素时,细胞形态和生长速度可能会受到干扰。
  • 重组人胰岛素已用在培养基中的间充质干细胞的成脂诱导。
  • 它已被用作气道上皮细胞的细胞培养基中的补充剂。
  • 它已用于细胞分化、GLUT4(4 型葡萄糖转运蛋白)易位测定的培养基中,并通过表面等离振子共振研究胰岛素与胰岛素受体的相互作用。

生化/生理作用

由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存,并抑制糖原、蛋白质和脂肪的分解。

其他说明

InChI:1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-400-113-180(307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137)213(354)274-109-196(342)280-177(110-323)239(380)301-173(100-145-106-270-120-276-145)233(374)293-165(91-126(13)14)237(378)315-202(128(17)18)247(388)287-157(73-80-198(345)346)215(356)277-133(25)210(351)289-160(86-121(3)4)224(365)296-169(96-141-55-63-147(330)64-56-141)229(370)292-164(90-125(11)12)236(377)316-203(129(19)20)250(391)311-181(114-401-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)

储存分类代码

11 - Combustible Solids

WGK

nwg

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

原产地证书 (CofO)

Tracey Pirali et al.
ChemMedChem, 12(18), 1542-1554 (2017-09-01)
Activation of the phosphoinositide 3-kinase (PI3K) pathway is a key signaling event in cancer, inflammation, and other proliferative diseases. PI3K inhibitors are already approved for some specific clinical indications, but their systemic on-target toxicity limits their larger use. In particular
Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life.
Laube M, et al.
PLoS ONE, 10, e0124833-e0124833 (2015)
Guokun Yang et al.
General and comparative endocrinology, 281, 137-144 (2019-06-10)
The insulin-like growth factor (IGF) system plays a pivotal role in the regulation of growth, and IGF binding proteins (IGFBPs) are important regulatory factors in the IGF system. Generally, IGFBPs inhibit IGF actions by preventing its binding to receptors. Under
Felix Weis et al.
Nature communications, 9(1), 4420-4420 (2018-10-26)
Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically
Zhuoyue Song et al.
Biochemical and biophysical research communications, 493(2), 1082-1088 (2017-09-20)
Mesenchymal stem cells (MSCs) are multipotent stromal cells residing in the bone marrow. MSCs have the potential to differentiate into adipocytes, chondrocytes, and other types of cells. However, the mechanism underlying MSC differentiation is still not fully understood. Here we

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门