A0980

AM281

≥98% (HPLC)

• 别名: 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide, AM 281
• 经验公式（希尔记法）: C₂₁H₁₉Cl₂IN₄O₂
• CAS Number: 202463-68-1
• 分子量: 557.21
• MDL號碼: MFCD01861180
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724384
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white
• 溶解度: DMSO: >6 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCOCC4
• InChI: 1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
• InChI 密鑰: AJFFBPZYXRNAIC-UHFFFAOYSA-N
• 基因資訊: rat ... Cnr1(25248)

说明

應用

AM281 has been used as a cannabinoid 1 receptor antagonist:

• to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice
• to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments
• to study its effect on scopolamine-induced memory deficit using object recognition paradigm
• to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain

生化／生理作用

AM281 is less lipophilic compared to its analog SR 141716A, a cannabinoid receptor antagonist. AM281 may prevent memory deficit post morphine withdrawal by inhibiting cannabinoid receptors in mice.

Potent and selective CB₁ cannabinoid receptor antagonist/inverse agonist

特點和優勢

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300,H315,H319,H335
• 防範說明: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges