Merck
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文件

A1106

Sigma-Aldrich

抗-ATM抗体，小鼠单克隆

clone MAT3-4G10/8, purified from hybridoma cell culture

所有图片(2)
别名:
抗共济失调毛细血管扩张突变
MDL编号:
MFCD01321740

生物来源

mouse

质量水平

200

重组

expressed in mouse cell line

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

MAT3-4G10/8, monoclonal

形式

PBS solution

分子量

antigen ~300 kDa

species reactivity

human, mouse

包装

antibody small pack of 25 μL

浓度

~2 mg/mL

technique(s)

immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract

同位素/亚型

IgG1

UniProt登记号

Q13315

运输

dry ice

储存温度

−20°C

Gene Information

human ... ATM(472)
mouse ... Atm(11920)

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M0691A6093MAB3806
Anti-ATM antibody,Mouse monoclonal clone MAT3-4G10/8, purified from hybridoma cell culture

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抗-ATM抗体，小鼠单克隆

Anti-Myosin VI antibody, Mouse monoclonal ~1 mg/mL, clone MUD-19, purified from hybridoma cell culture

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M0691

Anti-Myosin VI antibody, Mouse monoclonal

Anti-ATM antibody, Mouse monoclonal clone SYR6D4, purified from hybridoma cell culture

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A6093

Anti-ATM antibody, Mouse monoclonal

Sigma-Aldrich

Sigma-Aldrich

MAB3806

Anti-ATM phosphoSer1981 Antibody, clone 10H11.E12

recombinant

expressed in mouse cell line

recombinant

-

recombinant

-

recombinant

-

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

MAT3-4G10/8, monoclonal

clone

MUD-19, monoclonal

clone

SYR6D4, monoclonal

clone

10H11.E12, monoclonal

form

PBS solution

form

buffered aqueous solution

form

buffered aqueous solution

form

-

一般描述

单克隆抗ATM（小鼠IgG1同种型）源自通过小鼠骨髓瘤细胞（NSO）融合产生的杂交瘤MAT3-4G10/8和用肽免疫的BALB/c小鼠脾细胞。

特异性

单克隆抗ATM抗体与小鼠和人ATM发生特异性反应。

免疫原

跨越小鼠ATM的1967-1988位的肽，在其NH2末端含有与KLH偶联的半胱氨酸。

应用

ATM单克隆抗体可用于免疫印迹、ELISA和免疫沉淀。

生化/生理作用

抗共济失调毛细血管扩张突变（ATM）负责响应双链断裂（DSB）激活和稳定p53。ATM直接在Ser15上磷酸化p53，并同时激活其他激酶，这些激酶在其他位点磷酸化同一分子。此外，双分钟2（Hdm2）的人类同源物在Ser395上被ATM磷酸化，这种磷酸化抑制了Hdm2介导的p53降解。

外形

0.01 M磷酸盐缓冲液（pH 7.4，含有15 mM叠氮化钠）中的溶液

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
Pereg Y, et al.
Proceedings of the National Academy of Sciences of the USA, 102(14), 5056-5061 (2005)
Jasmin Roohi et al.
Journal of human genetics, 62(5), 581-584 (2017-01-27)
Ataxia-telangiectasia (A-T) is an autosomal recessive chromosome breakage disorder caused by mutations in the ATM gene. Typically, it presents in early childhood with progressive cerebellar dysfunction along with immunodeficiency and oculocutaneous telangiectasia. An increased risk of malignancy is also associated
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
Maya R, et al.
Genes & Development, 15(9), 1067-1067 (2001)
Marta Viana-Pereira et al.
PloS one, 6(5), e20588-e20588 (2011-06-04)
High grade gliomas (HGG) are one of the leading causes of cancer-related deaths in children, and there is increasing evidence that pediatric HGG may harbor distinct molecular characteristics compared to adult tumors. We have sought to clarify the role of
Armin M Gamper et al.
Nucleic acids research, 41(22), 10334-10344 (2013-09-17)
The kinase ATR is activated by RPA-coated single-stranded DNA generated at aberrant replicative structures and resected double strand breaks. While many hundred candidate ATR substrates have been identified, the essential role of ATR in the replicative stress response has impeded
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