Merck
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A1289

Sigma-Aldrich

蜂毒明肽

from bee venom, ≥95% (HPLC)

Empirical Formula (Hill Notation):
C79H131N31O24S4
CAS Number:
Molecular Weight:
2027.34
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

生物来源

bee venom

质量水平

200

测定

≥95% (HPLC)

形式

powder

储存温度

−20°C

SMILES string

CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCC[N@H]2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N3)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(N)=O)[C@@H](C)O

InChI

1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1

InChI key

YVIIHEKJCKCXOB-STYWVVQQSA-N

Gene Information

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Amino Acid Sequence

Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 [Disulfide Bridges: 1-11, 3-15]

一般描述

蜂毒明肽是蜂毒成分,本质上是强碱性的。它有18个氨基酸残基和两个二硫键。

应用

蜂毒明肽可用于:
  • 作为HEK细胞中小电导(SKCa)通道的选择性抑制剂。
  • 抑制内皮源性舒张因子(EDHF)介导的反应。
  • 在电生理研究中阻断上纹状体腹侧尾核(HVc)神经元中小电导Ca2激活的K电流(ISK)。

生化/生理作用

蜂毒明肽是一种神经毒素,对红细胞具有细胞毒性。暴露于蜂毒明肽会导致运动过度和抽搐。
已知唯一能通过血脑屏障的多肽神经毒素。阻断ATP型Ca2+激活的K+通道。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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