Merck
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文件

A2056

Sigma-Aldrich

乙酰辅酶A 三钠盐

≥93% (HPLC), powder

所有图片(7)
别名:
乙酰-S-CoA, 乙酰CoA
Empirical Formula (Hill Notation):
C23H35N7O17P3S · 3Na
CAS号:
102029-73-2
分子量:
875.52
MDL编号:
MFCD00078858
PubChem化学物质编号:
24890621

检测方案

≥93% (HPLC)

形式

powder

溶解性

H2O: 100 mg/mL

储存温度

−20°C

SMILES string

O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[3Na]

InChI

1S/C23H38N7O17P3S.Na/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);/q;+1/p-1/t13-,16-,17-,18?,22-;/m1./s1

InChI key

HNLIOWFIXSPFEC-WLYMNMRISA-M

Gene Information

human ... CHAT(1103) , HAT1(8520) , KAT2A(2648) , KAT2B(8850) , KAT5(10524)
mouse ... HAT1(107435) , KAT2A(14534) , KAT2B(18519) , KAT5(81601)
rat ... HAT1(296501) , KAT2A(303539) , KAT2B(301164) , KAT5(192218)

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A2181A3262G7637
Acetyl coenzyme A trisodium salt ≥93% (HPLC), powder

Sigma-Aldrich

A2056

乙酰辅酶A 三钠盐

Acetyl coenzyme A lithium salt ≥93% (HPLC)

Sigma-Aldrich

A2181

乙酰辅酶 A 锂盐

Adenosine 3′,5′-cyclic monophosphate tris salt ≥97% (HPLC), powder

Sigma-Aldrich

A3262

腺苷-3′,5′-环单磷酸 三羟甲基氨基甲烷盐

Guanosine 5′-[β-thio]diphosphate trilithium salt ≥85% (HPLC), powder

Sigma-Aldrich

G7637

鸟苷 5′-[β-硫代]二磷酸 三锂盐

form

powder

form

powder

form

powder

form

powder

solubility

H2O: 100 mg/mL

solubility

H2O: soluble 100 mg/mL, clear, colorless

solubility

H2O: 100 mg/mL

solubility

H2O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

Gene Information

human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)
mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)
rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218)

Gene Information

human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)
mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)
rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218)

Gene Information

-

Gene Information

-

应用

乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。 可通过线粒体中丙酮酸的氧化脱羧、长链脂肪酸的氧化或某些特定氨基酸的氧化降解，可形成乙酰辅酶A。乙酰辅酶A是柠檬酸循环（克雷布氏循环）的起始化合物。 同时，它也是脂质生物合成的关键前体、所有脂肪酸碳的来源。 乙酰辅酶A可正向调节丙酮酸羧化酶的活性。 乙酰辅酶A是神经递质乙酰胆碱的前体。 组蛋白乙酰化酶（HAT）使用乙酰辅酶A作为乙酰基的供体，用于组蛋白和非组蛋白蛋白的翻译后乙酰化反应。
酶促的乙酰转移反应中的必需辅助因子。

生化/生理作用

乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。 它可通过线粒体中丙酮酸的氧化脱羧、长链脂肪酸的氧化或某些特定氨基酸的氧化降解而形成。乙酰辅酶A是柠檬酸循环（克雷布氏循环）的起始化合物。 它也是脂质生物合成的关键前体，所有脂肪酸碳的来源。 乙酰辅酶A可正向调节丙酮酸羧化酶的活性。 它是神经递质乙酰胆碱的前体。 组蛋白乙酰化酶（HAT）使用乙酰辅酶A作为乙酰基的供体，用于组蛋白和非组蛋白蛋白的翻译后乙酰化反应。

制备说明

酶法制备

其他说明

如需更多技术信息以及辅酶A衍生物的完整列表，请访问乙酰转移试剂资源。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type N95 (US)

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