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COO原产地证书/COA分析证书

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A2942

Amphotericin B

Name: Amphotericin B
Brand: SIGMA

solution, suitable for cell culture, BioReagent

别名:

Amphotericin, Fungizone

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About This Item

经验公式（希尔记法）:

C₄₇H₇₃NO₁₇

CAS号:

1397-89-3

分子量:

924.08

MDL编号:

MFCD00877763

UNSPSC代码:

12352207

PubChem化学物质编号:

24890711

NACRES:

NA.76

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Slide 1 of 10

1 of 10

Sigma-Aldrich

A9528

两性霉素B，可溶

Sigma-Aldrich

A5955

抗生素抗霉菌溶液（100×），稳定

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G1397

庆大霉素溶液

Supelco

PHR1662

两性霉素 B

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A4888

两性霉素B 来源于链霉菌 属

Sigma-Aldrich

A2411

两性霉素B 来源于链霉菌 属

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G1272

庆大霉素溶液

Sigma-Aldrich

P4333

青链霉素

Sigma-Aldrich

N1638

制霉菌素悬浮液

Sigma-Aldrich

N9150

制霉菌素即用型溶液

产品名称

两性霉素 B 溶液, 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture

质量水平

200

无菌性

0.1 μm filtered

产品线

BioReagent

表单

liquid

浓度

250 μg/mL in deionized water

技术

cell culture | mammalian: suitable

颜色

yellow

抗生素抗菌谱

fungi
yeast

作用机制

cell membrane | interferes

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)O[Na])O2

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

APKFDSVGJQXUKY-INPOYWNPSA-N

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一般描述

两性霉素B是一种大环内酯，具有亲水性多羟基链和亲脂性多烯烃链。

应用

两性霉素B溶液已被用于：

作为腹腔注射剂用于治疗烟曲霉感染小鼠
作为中国美利奴绵羊卵巢培养的理想培养基的组成部分
在收集马黄体时用作运输培养基中的组成成分
作为RPMI培养基中的补充剂，用于培养小鼠-小鼠B细胞杂交瘤55-6细胞系

生化/生理作用

两性霉素B对真菌和酵母最有效。它通过结合与膜相关的固醇而形成跨膜通道，从而导致小分子的泄漏。尽管两性霉素B是治疗真菌病的有效抗生素，它会引起毒性。

两性霉素B是一种来自链霉菌的多烯抗真菌抗生素，临床上用于治疗系统性真菌感染。它对真菌和细菌细胞膜的固醇，尤其是麦角固醇具有很高的亲和力。维持抗真菌细胞培养的正常用量为2.5 mg/L，同时在培养基中使用青霉素和链霉素。

包装

20、50、100 ml

组分

该产品以250 μg/mL溶于去离子水中的两性霉素B提供。它是一种含有两性霉素B和以下提高其溶解度的组分组成的溶液：脱氧胆酸钠、氯化钠和磷酸钠。

注意

两性霉素B在37°C的培养条件下可保持活性3天。

制备说明

其在水溶液中形成沉淀是正常现象。对溶液进行混合可重新溶解大部分沉淀物，但是，如果无法完全溶解，两性霉素B仍然适合使用。

其他说明

保存于密闭容器内，置于干燥通风处。光敏感。

通常也和此产品一起购买

产品编号

说明

价格

890890P

18:1 TAP (DOTAP), Avanti Research^™ - A Croda Brand

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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其他客户在看

Slide 1 of 7

1 of 7

Sigma-Aldrich

A5955

抗生素抗霉菌溶液（100×），稳定

Sigma-Aldrich

P4333

青链霉素

Sigma-Aldrich

E3789

两性霉素 B-低内毒素

SAFC

55037C

汉克斯平衡盐溶液

Sigma-Aldrich

F4135

胎牛血清

Sigma-Aldrich

G1264

庆大霉素硫酸盐

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P0781

青链霉素

Analysis of kinetic, stoichiometry and regulation of glucose and glutamine metabolism in hybridoma batch cultures using logistic equations.

María Lourdes Acosta et al.

Cytotechnology, 54(3), 189-200 (2008-11-13)

Batch cultures were carried out to study the kinetic, stoichiometry, and regulation of glucose and glutamine metabolism of a murine hybridoma line. Asymmetric logistic equations (ALEs) were used to fit total and viable cell density, and nutrient and metabolite/product concentrations.

A newly identified derivative of amphotericin B: isolation, structure determination and primary evaluation of the activity and toxicity.

Yong-Hong Wang et al.

The Journal of antibiotics, 63(9), 553-557 (2010-07-08)

A new derivative of amphotericin B named amphotericin B(5) has been obtained under the following condition: amphotericin B powder was first dissolved in N,N-dimethylformamide at room temperature to obtain a solution of concentration of 2.0 mg ml(-1). Then, the solution

One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.

J Bolard et al.

Biochemistry, 30(23), 5707-5715 (1991-06-11)

The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtained with cholesterol- and ergosterol-containing egg yolk phosphatidylcholine large unilamellar vesicles (LUVs)

Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling.

Luigina Romani et al.

Blood, 103(11), 4232-4239 (2004-02-26)

Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha 1, a naturally occurring thymic peptide, induces functional maturation and interleukin-12

Modes of the antibiotic activity of amphotericin B against Candida albicans.

Ewa Grela et al.

Scientific reports, 9(1), 17029-17029 (2019-11-21)

Amphotericin B is an antibiotic used as the "gold standard" in the treatment of life-threatening fungal infections. Several molecular mechanisms have been proposed to explain exceptionally high effectiveness of amphotericin B in combating fungi. In the present work, we apply

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主要文件

Amphotericin B

solution, suitable for cell culture, BioReagent

About This Item

推荐产品

属性

产品名称

质量水平

无菌性

产品线

表单

浓度

技术

颜色

抗生素抗菌谱

作用机制

运输

储存温度

SMILES字符串

InChI

InChI key

相关类别

说明

一般描述

应用

生化/生理作用

包装

组分

注意

制备说明

其他说明

相关产品

通常也和此产品一起购买

890890P

安全信息

储存分类代码

WGK

闪点(°F)

闪点(°C)

个人防护装备

文件

分析证书(COA)

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