Merck
All Photos(3)

A3221

Sigma-Aldrich

碘乙酰胺

Single use vial of 56 mg

Linear Formula:
ICH2CONH2
CAS Number:
Molecular Weight:
184.96
Beilstein:
1739080
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.56

质量水平

200

测定

≥99% (HPLC)

形式

powder

包装

vial of 56 mg (Single use)

mp

92-95 °C (lit.)

溶解性

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

储存温度

2-8°C

SMILES string

NC(=O)CI

InChI

1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI key

PGLTVOMIXTUURA-UHFFFAOYSA-N

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应用

在肽测序和肽/蛋白质解析分析中,碘乙酰胺可用作半胱氨酸残基的烷化试剂它可用于二维蛋白质电泳,通过消除电泳过程中二硫化物形成可能导致的伪影,减少条纹并提高分辨率。由于其与半胱氨酸的反应,碘乙酰胺是酶的不可逆抑制剂,在活性位点具有半胱氨酸。它与组氨酸残基的反应速度要慢得多,但这种活性是核糖核酸酶抑制的原因。碘乙酰胺可用于二硫化物应激研究。

包装

10 vials in glass insert
密封安瓿包装

生化/生理作用

Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease.

法律信息

与蛋白质组系统合作开发的技术
Proteome Systems is a trademark of Proteome Systems Ltd

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificate of Analysis

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Certificate of Origin

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