Merck
所有图片(4)

文件

A3785

Sigma-Aldrich

5-氨基乙酰丙酸盐 盐酸盐

≥98%

所有图片(4)
别名:
δ-氨基乙酰丙酸盐 盐酸盐, 5-氨基-4-氧代戊酸 盐酸盐, 5-氨基乙酰丙酸盐 盐酸盐, ALA
线性分子式:
NH2CH2C(O)CH2CH2COOH · HCl
CAS号:
5451-09-2
分子量:
167.59
Beilstein:
3690651
EC 号:
226-679-5
MDL编号:
MFCD00012869
PubChem化学物质编号:
24890811
NACRES:
NA.26

质量水平

300

检测方案

≥98%

形式

powder

technique(s)

ligand binding assay: suitable

mp

150 °C

储存温度

−20°C

SMILES string

Cl[H].NCC(=O)CCC(O)=O

InChI

1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H

InChI key

ZLHFONARZHCSET-UHFFFAOYSA-N

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此商品
A557508339586757
5-Aminolevulinic acid hydrochloride ≥98%

Sigma-Aldrich

A3785

5-氨基乙酰丙酸盐 盐酸盐

Methyl δ-aminolevulinate hydrochloride ≥98% (TLC)

Sigma-Aldrich

A5575

5-氨基酮戊酸甲酯 盐酸盐

5-Aminolevulinic acid hydrochloride ≥97.0% (AT)

Sigma-Aldrich

08339

5-氨基乙酰丙酸盐 盐酸盐

5-Aminolevulinic acid-5-13C hydrochloride ≥99 atom % 13C, ≥99% (CP)

Sigma-Aldrich

586757

5-氨基酮戊酸-5-13C 盐酸盐

form

powder

form

powder

form

powder or crystals

form

solid

technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

mp

150 °C

mp

-

mp

~150 °C (dec.)

mp

156 °C (dec.) (lit.)

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

应用

5-氨基乙酰丙酸盐酸盐可以用来激活或抑制HeLa和K562细胞系中血红素生物合成。它用于A431肿瘤携带小鼠光动力治疗。

生化/生理作用

5-氨基乙酰丙酸（5-ALA）是血红素生物合成的中间物，可以用于治疗癌症。它是一种非蛋白氨基酸。5-ALA同样用于农业。它可用作基于转移性淋巴结荧光诊断原卟啉 IX (PPIX)抑制剂。5-ALA可以用于疾病光动力诊疗，比如Paget疾病和HPV感染有关的宫颈尖锐湿疣。
血红素生物合成中间体。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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USP

USP

1025726

Aminolevulinic acid Related Compound A

Sigma-Aldrich

Sigma-Aldrich

F5812

Fmoc-(S)-2-(5-azidopentane)Ala-OH

USP

USP

1025737

Aminolevulinic acid Related Compound B

4,6-Dioxoheptanoic acid powder

Sigma-Aldrich

D1415

4,6-二氧庚酸

Protoporphyrin IX ≥95%

Sigma-Aldrich

P8293

原卟啉 IX

Sigma-Aldrich

Sigma-Aldrich

SML1707

替莫泊芬

Treatment of HPV infection-associated cervical condylomata acuminata with 5-aminolevulinic acid-mediated photodynamic therapy.
Wang HW
Photochemistry and Photobiology, 88(3), 565-569 (2012)
ALA-PpIX variability quantitatively imaged in A431
epidermoid tumors using in vivo ultrasoundfluorescence
tomography and ex vivo assay
Alisha V DSouza
SPIE Proc., 8931 null
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation
Deborah Chiabrando, et.al
The Journal of Clinical Investigation, 122(12), 4569-4579 (2012)
Shigeru Kato et al.
The Journal of surgical research, 176(2), 430-436 (2012-01-10)
Lymph node metastasis is one of the most critical prognostic factors in patients with colorectal cancer. Although regional lymph nodes should be surgically resected and pathologically examined, techniques for the intraoperative diagnosis of lymph node metastasis remain to be well
Breann L Brown et al.
Structure (London, England : 1993), 26(4), 580-589 (2018-03-20)
5-Aminolevulinic acid synthase (ALAS) catalyzes the first step in heme biosynthesis. We present the crystal structure of a eukaryotic ALAS from Saccharomyces cerevisiae. In this homodimeric structure, one ALAS subunit contains covalently bound cofactor, pyridoxal 5'-phosphate (PLP), whereas the second
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