所有图片(4)

A4034

Sigma-Aldrich

(+)-抗坏血酸钠 L

powder, BioReagent, suitable for cell culture

别名:
L(+)-抗坏血酸 钠盐, 维生素 C 钠盐
Empirical Formula (Hill Notation):
C6H7NaO6
CAS号:
分子量:
198.11
Beilstein:
3767246
EC 号:
MDL编号:
eCl@ss:
34058010
PubChem化学物质编号:
NACRES:
NA.75

质量水平

200

生物来源

synthetic (organic)

产品线

BioReagent

测定

≥98%

形式

powder

分子量

Mw 135.13 g/mol

应用

cell culture | mammalian: suitable
cell culture | plant: suitable

颜色

white to off-white

mp

220 °C (dec.) (lit.)

溶解性

H2O: 50 mg/mL

SMILES string

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

InChI

1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

InChI key

PPASLZSBLFJQEF-RXSVEWSESA-M

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一般描述

(+)-L-抗坏血酸钠(SA)是潜在的抗氧化剂,是维生素C(L-抗坏血酸)的衍生物。作为食品添加剂,广泛应用。此外,SA还增强硫酸博来霉素、R020-1724(环状核苷酸磷酸二酯酶抑制剂)、前列腺素E1和丁酸钠等物质的生长阻滞活性,这一活性对培养的神经母细胞瘤细胞有作用。升高的SA水平会诱发大鼠二期膀胱癌。 L-抗坏血酸钠与胶原蛋白生成抑制剂联合用于治疗皮肤疤痕和瘢痕疙瘩。

应用

用于制备植物提取物;用于分离叶绿体的还原剂。
(+)-L-抗坏血酸钠用于:
  • 在细胞培养基中,产生过H2O2
  • 作为还原剂,还原可渗透细胞人工电子供体(N,N,N,′N′-四甲基对苯二胺(TMPD))
  • 研究其对源自正常人体皮肤和真皮脂肪成纤维细胞培养物中胶原蛋白和弹性纤维产量的影响

包装

1 kg in poly bottle
100, 500 g in poly bottle

生化/生理作用

抗氧化剂

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

原产地证书 (CofO)

Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats
Fukushima S, et al.
Cancer Research, 43(9), 4454-4457 (1983)
Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture
Prasad KN, et al.
Proceedings of the National Academy of Sciences of the USA, 76(2), 829-832 (1979)
Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media
Long LH and Halliwell B
Biochemical and Biophysical Research Communications, 388(4), 700-704 (2009)
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
Bordt EA, et al.
Developmental Cell, 40(6), 583-594 (2017)
Artefacts in cell culture: alpha-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media
Long LH and Halliwell B
Biochemical and Biophysical Research Communications, 406(1), 20-24 (2011)

技术文章

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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