Merck

A6885

Sigma-Aldrich

腺苷 3',5'-环单磷酸 钠盐 一水合物

≥98.0% (HPLC), powder

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别名:
cAMP-Na, 环化腺苷酸 钠盐
Empirical Formula (Hill Notation):
C10H11N5NaO6P · H2O
CAS号:
分子量:
369.20
Beilstein:
54612
MDL编号:
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98.0% (HPLC)

形式

powder

颜色

white

溶解性

H2O: 10 mg/mL

储存温度

−20°C

SMILES string

[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1

InChI key

BXJBFCKTIWRKMQ-MCDZGGTQSA-M

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此商品
A9501A9376D0260
form

powder

form

powder

form

powder

form

powder

color

white

color

white

color

-

color

white

solubility

H2O: 10 mg/mL

solubility

H2O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)

solubility

water: 50 mg/mL, clear, colorless

solubility

H2O: 100 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

应用

腺苷-3′,5′-环磷酸(cAMP) 是环腺苷酸依赖性蛋白激酶A(PKA)的激活剂。 已有研究表明cAMP/PKA信号传导途径能够抑制细胞增殖、诱导分化并导致细胞凋亡。 外源性cAMP在心肌的自发性活动和收缩中发挥作用。

生化/生理作用

环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使,并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示,cAMP/PKA 信号通路可抑制细胞增殖,诱导分化并导致细胞凋亡。

特点和优势

《受体分类和信号转导》手册的 磷酸二酯酶以及PKA & PKG页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物是环核苷酸研究推荐产品。点击此处 ,查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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W Tuganowski et al.
Polish journal of pharmacology and pharmacy, 30(4), 451-454 (1978-07-01)
Isotonic solution of cAMP-Na was applied into spontaneously beating auricular fibres by a cut-end method. Cyclic AMP enhanced the spontaneous rate (mean 48%) and increased the contractile tension (mean 297%). These results provided direct evidence that cAMP is involved in
Corinne Giusti et al.
Experimental cell research, 315(1), 26-38 (2008-10-28)
Dictyostelium atg1- mutant cells provide an experimentally and genetically favorable model to study necrotic cell death (NCD) with no interference from apoptosis or autophagy. In such cells subjected to starvation and cAMP, induction by the differentiation-inducing factor DIF or by
Logan A Collier et al.
mBio, 11(6) (2020-11-26)
The filamentous fungus Neurospora crassa decomposes lignocellulosic biomass to generate soluble sugars as carbon sources. In this study, we investigated a role for heterotrimeric G-protein signaling in cellulose degradation. Loss of the Gα subunit genes gna-1 and gna-3, the Gβ
Connor M Blair et al.
Bio-protocol, 10(7), e3581-e3581 (2021-03-05)
Cyclic nucleotide degrading phosphodiesterase (PDE) enzymes are crucial to the fine tuning of cAMP signaling responses, playing a pivotal role in regulating the temporal and spatial characteristics of discrete cAMP nanodomains and hence the activity of cAMP-effector proteins. As a
U Dunzendorfer et al.
European urology, 8(6), 363-366 (1982-01-01)
Patients with a history of idiopathic calcium oxalate stones, but without current stone formation, show distinctly higher levels of serum cAMP (cyclic adenosine 3',5'-monophosphate) after rapid injection of an extreme concentration of parathyroid extract (PTE). Extreme parathyroid hormone (PTH) levels

商品

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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