所有图片(4)

A7007

Sigma-Aldrich

S-(5′-腺苷)-L-甲硫氨酸氯化物 二盐酸盐

≥75%

别名:
活性加硫氨酸, SAM氯化物 二盐酸盐, AdoMet
Empirical Formula (Hill Notation):
C15H23ClN6O5S · 2 HCl
CAS号:
分子量:
507.82
Beilstein:
6560002
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

质量水平

300

测定

≥75%

形式

powder

应用

cell analysis: suitable

颜色

white to off-white

溶解性

H2O: 100 mg/mL

运输

dry ice

储存温度

−20°C

SMILES string

Cl.Cl.[Cl-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C15H22N6O5S.3ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;;;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);3*1H/t7-,8+,10+,11+,14+,27?;;;/m0.../s1

InChI key

KBAFOJZCBYWKPU-XQVUROGGSA-N

正在寻找类似产品? Visit 产品对比指南

相关类别

一般描述

S-(5′-腺苷)-L-蛋氨酸氯化二盐酸盐(SAM)有助于将甲基基团转移到蛋白质,脂类和核酸上。蛋氨酸腺苷基转移酶催化从蛋氨酸和腺苷三磷酸(ATP)合成SAM。SAM能够调节各种细胞功能,比如细胞分裂,细胞死亡,翻译,遗传稳定性,氧化剂/抗氧化剂平衡和聚胺平衡。从治疗上来说,SAM可用作人体营养补充剂,用于多种疾病比如骨关节炎和肝脏损伤。SAM还能调节转硫化反应,通过和关键酶硫醚-β-合成酶(CBS)调控域结合实现。

应用

S-(5′-腺苷)-L-甲硫氨酸氯化二盐酸盐(SAM)被用作S30细胞提取物培养基补充剂。通过石英晶体微平衡(QCM),表面等离子共振(SPR)和等温滴定量热(ITC),它可以用来测量苯邻二酚-O-甲基转移酶(COMT)和支撑脂双层以及载体互作。

包装

5 mg in glass bottle
25, 100, 500 mg in poly bottle
1 g in poly bottle

生化/生理作用

甲基供体;甲基酶催化辅因子,包括儿茶酚O-甲基转移酶(COMT)和DNA甲基转移酶(DNMT)。 尽管存在于所有细胞中,它主要集中在肝脏中,这里是85%甲基化反应发生的地方。 它同样参与了调节肝脏功能,生长和伤害应答。

注意

这种材料在制备是是80%-90%纯,但是非常不稳定。已经有记录每天在25℃能够损伤10%纯度。

分析说明

纯度基于UV和HPLC。

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Andria V Rodrigues et al.
Chembiochem : a European journal of chemical biology, 21(5), 663-671 (2019-09-13)
We recently reported the discovery of phenylacetate decarboxylase (PhdB), representing one of only ten glycyl-radical-enzyme reaction types known, and a promising biotechnological tool for first-time biochemical synthesis of toluene from renewable resources. Here, we used experimental and computational data to...
Ted M Lakowski et al.
Analytical biochemistry, 396(1), 158-160 (2009-09-08)
S-Adenosyl-L-homocysteine (AdoHcy) background signal in reactions with protein arginine N-methyltransferase 1 is investigated using an ultrahigh-performance liquid chromatography tandem mass spectrometry assay that measures AdoHcy. We identify three sources of AdoHcy background: enzymatic automethylation, AdoHcy contamination in commercial S-adenosyl-L-methionine (AdoMet)...
S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau.
Beauchamp, et al.
Journal of Alzheimer'S Disease, 77, 1705-1715 (2021)
Yunpeng Shen et al.
Structure (London, England : 1993), 27(4), 631-638 (2019-02-19)
Histone methylation by histone methyltransferases (HMTases) has a key role in transcriptional regulation. Discrepancies between the known HMTases and the histone lysine methylome suggest that HMTases remain to be identified. Here we report the discovery, characterization, and crystal structure of...
Chemical communication between bacteria and cell-free gene expression systems within linear chains of emulsion droplets
Schwarz-Schilling M, et al.
Integrative Biology : Quantitative Biosciences from Nano to Macro, 8(4), 564-570 (2016)

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门