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A7755

Sigma-Aldrich

5α-雄甾烷-3α,17β-二醇

别名:

3α,17β-二羟基-5α-雄甾烷, 二氢雄甾酮

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About This Item

经验公式（希尔记法）:
C19H32O2
CAS号:
1852-53-5
分子量:
292.46
EC 号:
217-447-4
MDL编号:
MFCD00003676
UNSPSC代码:
51111800
PubChem化学物质编号:
24278236
NACRES:
NA.77

方案

≥98% (TLC)

质量水平

200

表单

powder

药品控制

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

技术

toxicology assay: suitable

溶解性

methanol: 19.60-20.40 mg/mL, clear, colorless

储存温度

room temp

SMILES字符串

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,17-,18-,19-/m0/s1

InChI key

CBMYJHIOYJEBSB-KHOSGYARSA-N

基因信息

rat ... Ar(24208)

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应用

5α-Androstane-3α,17β-diol (dihydroandrosterone) is a testosterone metabolite. Dihyroandrosterone inhibited the cell growth of seven cancer cell lines while showing weak toxicity on normal cell lines.

生化/生理作用

Dihydroandrosterone is a testosterone metabolite; affects sperm maturation and survival.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H351,H360FD

预防措施声明

P201 - P308 + P313

危险分类

Carc. 2 - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCR4586
0000225017
0000235325
0000235324
0000194353

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L Kancheva et al.
Steroids, 72(11-12), 792-801 (2007-08-25)
Certain androstane steroids (AS) modulate ionotropic receptors, as do the pregnane steroids. Whereas women produce significant amounts of neuroactive progesterone metabolites, the steroid neuromodulators in men originate mainly from the 3-oxo-4-ene C(19)-steroids, which are converted to their 3alpha- and 3beta-hydroxy-5alpha/5beta-reduced
Effect of testosterone, its 5 alpha-reduced metabolites and the corresponding propionates on testosterone metabolism. I--In the hypothalamus and in the anterior pituitary.
F Celotti et al.
Journal of steroid biochemistry, 11(1A), 215-219 (1979-07-01)
17α-ethynyl-5α-androstane-3α, 17β-diol treatment of MNU-induced mammary cancer in rats
Ahlem, C., et al.
International Journal of Breast Cancer, doi: 10-doi: 10 (2011)
B Eckstein et al.
Biochimica et biophysica acta, 627(2), 165-171 (1980-01-17)
Serum testosterone levels are elevated prior to the lutropin surge, and decline abruptly following the release of endogenous lutropin. To investigate this phenomenon, the activity of 17 beta-hydroxysteroid dehydrogenase, the enzyme directly related to testosterone production from androstenedione, was measured.
Effect of testosterone, its 5 alpha-reduced metabolites and the corresponding propionates on testosterone metabolism--II. In the ventral prostate and in the seminal vesicles.
F Celotti et al.
Journal of steroid biochemistry, 11(1A), 221-225 (1979-07-01)
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