Merck
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A8346

Sigma-Aldrich

ProteoMass ACTH 片段 18-39 MALDI-MS 标准品

vial of 10 nmol, monoisotopic mol wt 2,464.1989 Da

Synonym(s):
促肾上腺皮质激素片段 18-39
CAS Number:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

质量水平

100

分子量

monoisotopic mol wt 2,464.1989 Da

包装

vial of 10 nmol

SMILES string

CC(C)CC(NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(Cc4ccc(O)cc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(C)C)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(Cc6ccccc6)C(O)=O

InChI

1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)

InChI key

ZYDMZKPAPSZILB-UHFFFAOYSA-N

Amino Acid Sequence

Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

一般描述

单个肽或蛋白质标准品用于校准和测试基质辅助激光解吸电离 (MALDI) 质谱仪。促肾上腺皮质激素 (ACTH) 是由其前体阿黑皮素原 (POMC) 合成的。在下丘脑促肾上腺皮质激素释放激素 (CRH) 的作用下,由垂体前叶释放。

应用

MALDI-MS 仪器用多肽校准标准品;1 瓶含 10 nmol。
已将 ProteoMass ACTH 片段 18-39 MALDI-MS 标准品用作基质辅助激光解吸/离子化 (MALDI)-质谱 (MS) 仪器的肽校准标准品。

生化/生理作用

促肾上腺皮质激素 (ACTH) 通过肾上腺的 G 蛋白偶联受体介导 cAMP 依赖的糖皮质激素和雄激素的合成与释放。ACTH 的过度产生导致明显的皮肤色素沉着。

储存及稳定性

各标准品在室温下储存,并在环境温度下运输。标准品贮备液可以等分冷冻,但冻融循环不应超过 3 次。推荐复溶后使用标准品溶液不超过一个月。

法律信息

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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Articles

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