Merck

A9187

Sigma-Aldrich

Adenosine 5′-triphosphate 镁盐

≥95%, bacterial

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别名:
ATP 镁盐
Empirical Formula (Hill Notation):
C10H16N5O13P3 · xMg2+
CAS号:
分子量:
507.18 (free acid basis)
MDL编号:
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51

生物来源

bacterial

质量水平

检测方案

≥95%

形式

powder

溶解性

H2O: 50 mg/mL

储存温度

−20°C

SMILES string

[Mg].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H16N5O13P3.Mg.2H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;

InChI key

CPGAIACWYFBIFN-UHFFFAOYSA-N

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此商品
A2383A3377A7699
assay

≥95%

assay

≥99%

assay

≥97% (HPLC)

assay

≥99% (HPLC)

form

powder

form

powder

form

crystalline

form

powder

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL, clear, colorless

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

应用

腺苷5′-三磷酸镁盐已可用于:
  • 作为细胞内Ca2+ 保留测定和荧光广域成像分析的补充剂
  • 作为甲烷磺酸钾内溶物的一种成分,用于皮层神经元的 体外 电生理研究
  • 作为细胞内电位溶液中起作用的组分

生化/生理作用

腺苷5γ-三磷酸腺苷(ATP)是体内能量储存和代谢的中心成分。 ATP应用于许多细胞过程、呼吸、生物合成反应、运动和细胞分裂。ATP是许多激酶的底物,这些激酶参与细胞信号和腺苷酸环化酶(s),产生第二个信使 cAMP。 ATP提供代谢能量来驱动代谢泵。 ATP在一系列酶促反应中充当辅酶。
P2 嘌呤能激动剂;增加 Ca2+-激活的 K+ 通道的活性;ATP-依赖酶系统的底物

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

STOT SE 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable


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Lea Wagmann et al.
Archives of toxicology, 92(9), 2875-2884 (2018-08-08)
Transporter-mediated drug-drug interactions (DDI) may induce adverse clinical events. As drugs of abuse (DOA) are marketed without preclinical safety studies, only very limited information about interplay with membrane transporters are available. Therefore, 13 DOA of various classes were tested for
Spatial separation of mitochondrial calcium uptake and extrusion for energy-efficient mitochondrial calcium signaling in the heart.
De La Fuente S, et al.
Cell reports, 24(12), 3099-3107 (2018)
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
Fenske S, et al.
Nature Protocols, 11(1), 61-61 (2016)
A subpopulation of striatal neurons mediates Levodopa-induced dyskinesia.
Girasole AE, et al.
Neuron, 97(4), 787-795 (2018)
Lea Wagmann et al.
Journal of chromatography. A, 1521, 123-130 (2017-09-28)
Interactions with the human breast cancer resistance protein (hBCRP) significantly influence the pharmacokinetic properties of a drug and can even lead to drug-drug interactions. As efflux pump from the ABC superfamily, hBCRP utilized energy gained by adenosine 5'-triphosphate (ATP) hydrolysis

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