所有图片(1)

A9525

Sigma-Aldrich

人血管紧张素 II

≥93% (HPLC), powder

别名:
Angiotensin 2, Angiotensin II, Ang II, DRVYIHPF
Empirical Formula (Hill Notation):
C50H71N13O12
CAS号:
分子量:
1046.18
eCl@ss:
42020611
PubChem化学物质编号:
NACRES:
NA.32

质量水平

200

生物来源

synthetic

测定

≥93% (HPLC)

形式

powder

应用

cell culture | mammalian: suitable

杂质

1.2-10.4% acetate

UniProt登记号

储存温度

−20°C

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Gene Information

human ... AGT(183)

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

应用

  • Angiotensin II (angII) human has been used to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.
  • It has been used to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.
  • It has been used to study the actions of systemic angII infusions on glomerular permeability in vivo.
  • It has been used to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.

生化/生理作用

Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. AngII in blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. AngII is a component of the renin-angiotensin system. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, modulation of myocardial hypertrophy, renal failure and fibrosis.

特点和优势

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

抗体吸附剂

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O

分析说明

肽含量不低于 75%

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

原产地证书 (CofO)

Mengxia Fu et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(8), 1629-1644 (2019-06-14)
Periaortic arch adipose tissue (PAAT) plays critical roles in regulating vascular homeostasis; however, its anatomic features, developmental processes, and origins remain unclear. Approach and Results: Anatomic analysis and genetic lineage tracing of Wnt1 (wingless-type MMTV [mouse mammary tumor virus] integration
Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.
Vaughan DE et al.
The Journal of Clinical Investigation, 95, 995-995 (1995)
Angiotensin II as a pro-inflammatory mediator.
Phillips MI and Kagiyama S
Current Opinion in Investigational Drugs, 3, 569-569 (2002)
Angiotensin II and renal fibrosis.
Mezzano SA et al.
Hypertension, 38, 635-635 (2001)
Angiotensin II-forming pathways in normal and failing human hearts.
Urata H et al.
Circulation Research, 66, 883-883 (1990)

技术文章

Lipid-induced Insulin Resistance

Lipid Induced Insulin Resistance

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门