HCLS1 is a mitochondrial protein that is predominantly expressed in cardiac and skeletal tissues. This protein is known to interact with HAX1 and LEF-1 which, in turn, regulates granulocyte colony-stimulating factor (G-CSF)-mediated granulopoiesis.
Rabbit Anti-HCLS1 antibody recognizes human, rat, mouse, chicken, canine, bovine, and zebrafish HCLS1.
Synthetic peptide directed towards the N terminal region of human HCLS1
Rabbit Anti-HCLS1 (AB2) antibody can be used for western blot applications at a concentration of 1.25μg/ml.
HS1 which is hematopoietic lineage cell-specific protein 1, is a substrate of protein tyrosine kinases in lymphocytes, it binds to F-actin, and promotes Arp2/3 complex-mediated actin polymerization. However, the mechanism for the interaction between HS1 and F-actin has not yet been fully characterized. HS1 contains 3.5 tandem repeats, a coiled-coil region, and an SH3 domain at the C terminus. Unlike cortactin, which is closely related to HS1 and requires absolutely the repeat domain for F-actin binding, an HS1 mutant with deletion of the repeat domain maintains a significant F-actin binding activity. Deletion of the coiled-coil region abolished the ability of HS1 to bind to actin filaments and to activate the Arp2/3 complex for actin nucleation and actin branching.
Synthetic peptide located within the following region: FGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAV
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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