AV35326

Sigma-Aldrich

Anti-KCNK10 (AB2) antibody produced in rabbit

IgG fraction of antiserum

别名:
Anti-Potassium channel, subfamily K, member 10
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

59 kDa

species reactivity

rabbit, guinea pig, human

concentration

0.5 mg - 1 mg/mL

application(s)

western blot: suitable

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... KCNK10(54207)

General description

KCNK10 (TREK2) codes for a potassium channel protein that is activated by 2-aminoethoxydiphenyl borate (2-APB). TREK2 is known to be expressed in normal and cancerous ovarian cells.
Rabbit Anti-KCNK10 antibody recognizes rabbit, human, mouse, rat, and canine KCNK10.

Immunogen

Synthetic peptide directed towards the C terminal region of human KCNK10

Application

Rabbit Anti-KCNK10 antibody is suitable for western blot applications at a concentration of 1.4 μg/ml.

Biochem/physiol Actions

KCNK10 is one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is highly expressed in the kidney and pancreas. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. The protein is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Three transcript variants have been identified for this gene.

Sequence

Synthetic peptide located within the following region: QGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEK

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

分析证书
原产地证书 (CofO)
Leopoldo Beltrán et al.
Frontiers in pharmacology, 4, 63-63 (2013-05-31)
Two-pore domain K(+) (KCNK, K2P) channels underlie the "leak" (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability. These channels have been reported to be modulated by several physical and chemical stimuli. The...
A Innamaa et al.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 15(11), 910-918 (2013-03-13)
Aberrant expression of potassium (K(+)) channels contributes to cancer cell proliferation and apoptosis, and K(+) channel blockers can inhibit cell proliferation. TREK-1 and -2 belong to the two-pore domain (K2P) superfamily. We report TREK-1 and -2 expression in ovarian cancer...
Zhaoyang Xiao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(20), 7027-7042 (2014-05-16)
Neurotensin (NT) is a tridecapeptide distributed in the CNS, including the entorhinal cortex (EC), a structure that is crucial for learning and memory and undergoes the earliest pathological alterations in Alzheimer's disease (AD). Whereas NT has been implicated in modulating...

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