TIPIN forms a complex with TIMELESS and regulates the stabilization of replication forks. This complex facilitates the cohesion of sister chromatids. It is also involved in Chk1 phosphorylation by ATR during genotoxic stress response.
Rabbit Anti-TIPIN antibody recognizes canine, bovine, human, mouse, and rat TIPIN.
Synthetic peptide directed towards the middle region of human TIPIN
Rabbit Anti-TIPIN antibody is suitable for western blot applications at a concentration of 1μg/ml.
TIPIN belongs to the CSM3 family. TIPIN is required for normal progression of S-phase. It is important for cell survival after DNA damage or replication stress. TIPIN may be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.
Synthetic peptide located within the following region: SESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLM
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.