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AV54779

Anti-LGALS3BP antibody produced in rabbit

affinity isolated antibody

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别名:

Anti-90K, Anti-Lectin, galactoside-binding, soluble, 3 binding protein, Anti-MAC-2-BP

NACRES:

NA.41

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此商品	SAB4100313	HPA030491	AB10541
Sigma-Aldrich AV54779 Anti-LGALS3BP antibody produced in rabbit	Sigma-Aldrich SAB4100313 Monoclonal Anti-LGALS3BP antibody produced in mouse	Sigma-Aldrich HPA030491 Anti-LGALS8 antibody produced in rabbit	Sigma-Aldrich AB10541 Anti-Galectin-3 Antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
antibody form affinity isolated antibody	antibody form culture supernatant	antibody form affinity isolated antibody	antibody form affinity isolated antibody
clone polyclonal	clone LGALS3BP-A265, monoclonal	clone polyclonal	clone polyclonal
form buffered aqueous solution	form aqueous solution	form buffered aqueous glycerol solution	form -
mol wt 63 kDa	mol wt antigen predicted mol wt 65.2 kDa	mol wt -	mol wt -

免疫原

Synthetic peptide directed towards the middle region of human LGALS3BP

应用

Anti-LGALS3BP antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

生化/生理作用

LGALS3BP (Lectin, galactoside-binding, soluble, 3 binding protein) or MAC-2-BP gene encodes a Galectin-3-binding protein localized to chromosome 17q25. It is widely expressed by keratinocytes and fibroblasts but is also present in fluids like- semen, milk, serum, tears, saliva and urine. LGALS3BP stimulates the intergrin-mediated cell adhesion. It also imposes stimulatory impact on host defense system like natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Furthermore, the encoded protein interacts specifically with galectin-1 and galectin-3 and facilitates the formation of multicell aggregates.

序列

Synthetic peptide located within the following region: NLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTS

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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The secreted tumor-associated antigen 90K is a potent immune stimulator.

A Ullrich et al.

The Journal of biological chemistry, 269(28), 18401-18407 (1994-07-15)

Immunization of mice with conditioned media from human breast cancer cells yielded the monoclonal antibody SP-2, which recognized an antigen of approximately 90-95 kDa. This protein, designated 90K, was found to be present in the serum of healthy individuals and

Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation.

N Tinari et al.

International journal of cancer, 91(2), 167-172 (2001-01-09)

The glycoprotein 90K was originally described as a tumor-secreted antigen and subsequently found to have immunostimulatory activity as well as other possible functions. This protein interacts with an endogenous lectin, galectin-3, and may play a role in tumor metastasis through

Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain.

K Koths et al.

The Journal of biological chemistry, 268(19), 14245-14249 (1993-07-05)

We have purified and sequenced a secreted glycoprotein from both the human breast carcinoma cell line, SK-BR-3, and human breast milk. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2. This Mac-2 binding protein (Mac-2-BP) has

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Anti-LGALS3BP antibody produced in rabbit

affinity isolated antibody

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