Merck
All Photos(3)

B2643

Sigma-Aldrich

生物素酰胺己酸 N-羟基琥珀酰亚胺酯

≥98% (TLC), powder

Synonym(s):
(+)-生物素氨基己酸酯 N-羟基琥珀酰亚胺酯, 6-己酸琥珀酰亚胺酯, N-(+)-生物素-6-氨基己酸 N-琥珀酰亚胺酯, N-(+)-生物素-6-氨基己酸 NHS 酯, N-琥珀酰亚胺基 N-生物素基-6-氨基己酸酯
Empirical Formula (Hill Notation):
C20H30N4O6S
CAS Number:
Molecular Weight:
454.54
Beilstein:
3577403
MDL编号:
PubChem化学物质编号:
NACRES:
NA.46

质量水平

200

测定

≥98% (TLC)

形式

powder

溶解性

H2O: ≤2 mg/mL (with sonication)
DMF: 50 mg/mL (Stable up to 2 months in dry DMF.)

储存温度

−20°C

SMILES string

[H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2

InChI

1S/C20H30N4O6S/c25-15(7-4-3-6-14-19-13(12-31-14)22-20(29)23-19)21-11-5-1-2-8-18(28)30-24-16(26)9-10-17(24)27/h13-14,19H,1-12H2,(H,21,25)(H2,22,23,29)/t13-,14-,19-/m0/s1

InChI key

UVGHPGOONBRLCX-NJSLBKSFSA-N

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应用

Biotinamidohexanoic acid N-hydroxysuccinimide ester has been used in the biotinylation of antibodies.[1][2][3]

包装

10, 25, 100, 250 mg in poly bottle

生化/生理作用

Biotin is a label widely used in several biochemical applications and has a high affinity for avidin. A spacer chain is required to reduce steric hindrance while coupling biotin (a small molecule) to biopolymers (large molecules). Biotinamidohexanoic acid N-hydroxysuccinimide ester incorporates a 7-atom spacer with the N-succinimide leaving group. It can react with a primary amine in the pH range of 6.5-8.5. This biotinylation reagent incorporates an aminocaproyl spacer and thus can reduce the steric hindrance in binding avidin to some biotinylated compounds.

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储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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