B3259

缓激肽 乙酸盐

powder, ≥98% (HPLC)

• Empirical Formula (Hill Notation): C₅₀H₇₃N₁₅O₁₁ · xC₂H₄O₂
• CAS Number: 6846-03-3
• Molecular Weight: 1060.21 (free base basis)
• EC 号: 227-781-2
• NACRES: NA.32

Properties

• 质量水平: 100
• 测定: ≥98% (HPLC)
• 形式: powder
• 储存条件: desiccated
• 颜色: white
• 溶解性: 0.1 M acetic acid: 25 mg/mL, clear, colorless
• UniProt登记号: P01042
• 储存温度: −20°C
• InChI: 1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
• InChI key: QXZGBUJJYSLZLT-FDISYFBBSA-N
• Gene Information: human ... KNG1 (includes EG:3827)

Description

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

应用

Bradykinin acetate salt has been used:

• to stimulate the contraction of guinea pig ileum
• as a contractile agent in fibroblasts
• In the stimulation of endothelium of human subcutaneous artery
• To evoke Ca²⁺ signals in neuroblastoma-glioma hybrid cell line, NG108-15

生化/生理作用

缓激肽是一种促炎肽，通过 G-蛋白质偶联受体进行作用。它活化鞘脂类的代谢。经缓激肽处理的成纤维细胞的神经酰胺分泌量会有快速而重大的增长，随后鞘氨醇含量也会短暂上升。这种肽也会通过使中性糖脂快速移动来增加细胞的神经酰胺含量。缓激肽在体液和电解质平衡的调节、平滑肌收缩、血管舒张和毛细血管通透性方面都发挥着重要的作用。缓激肽增效剂本身不具有缓激肽活性，但能增强缓激肽的活性。

Safety Information

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)