Merck

B3259

Sigma-Aldrich

缓激肽 乙酸盐

powder, ≥98% (HPLC)

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经验公式(希尔记法):
C50H73N15O11 · xC2H4O2
CAS号:
分子量:
1060.21 (free base basis)
EC 号:
NACRES:
NA.32

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white

溶解性

0.1 M acetic acid: 25 mg/mL, clear, colorless

UniProt登记号

储存温度

−20°C

InChI

1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

InChI key

QXZGBUJJYSLZLT-FDISYFBBSA-N

基因信息

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此商品
H4884S8758H7278
缓激肽 乙酸盐 powder, ≥98% (HPLC)

B3259

缓激肽 乙酸盐

Hippuryl-His-Leu acetate salt

H4884

Hippuryl-His-Leu acetate salt

NG-羟基-L-精氨酸 乙酸盐

H7278

NG-羟基-L-精氨酸 乙酸盐

solubility

0.1 M acetic acid: 25 mg/mL, clear, colorless

solubility

acetic acid: 50 mg/mL, clear, colorless to very faintly yellow

solubility

50% acetic acid: 1 mg/mL, clear, colorless

solubility

acetic acid: 10 mg/mL, clear, colorless to faintly yellow

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98%

assay

≥98% (TLC)

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white

color

-

color

-

color

-

UniProt accession no.

P01042

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

-

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

应用

Bradykinin acetate salt has been used:
  • to stimulate the contraction of guinea pig ileum
  • as a contractile agent in fibroblasts
  • In the stimulation of endothelium of human subcutaneous artery
  • To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15

生化/生理作用

缓激肽是一种促炎肽,通过 G-蛋白质偶联受体进行作用。它活化鞘脂类的代谢。经缓激肽处理的成纤维细胞的神经酰胺分泌量会有快速而重大的增长,随后鞘氨醇含量也会短暂上升。这种肽也会通过使中性糖脂快速移动来增加细胞的神经酰胺含量。缓激肽在体液和电解质平衡的调节、平滑肌收缩、血管舒张和毛细血管通透性方面都发挥着重要的作用。缓激肽增效剂本身不具有缓激肽活性,但能增强缓激肽的活性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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