Merck
  • B5556
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B5556

Sigma-Aldrich

Bay 11-7082

≥98% (HPLC), powder

All Photos(1)
Synonym(s):
（E）-3-（4-甲苯磺酰基）-2-丙烯腈
Empirical Formula (Hill Notation):
C10H9NO2S
CAS Number:
19542-67-7
Molecular Weight:
207.25
MDL编号:
MFCD00712162
PubChem化学物质编号:
24891842
NACRES:
NA.77

Recommended Products

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BAY 11-7082 - CAS 19542-67-7 - Calbiochem The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

196870

BAY 11-7082 - CAS 19542-67-7 - Calbiochem

The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

Sigma-Aldrich

196871

InSolution BAY 11-7082 - Calbiochem

Bay 11-7085 ≥98% (HPLC), solid

Sigma-Aldrich

B5681

Bay 11-7085

≥98% (HPLC), solid

SP600125 ≥98% (HPLC)

Sigma-Aldrich

S5567

SP600125

≥98% (HPLC)

NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

481412

NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem

The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

SB 203580 solid, ≥98% (HPLC)

Sigma-Aldrich

S8307

SB 203580

solid, ≥98% (HPLC)

JSH-23 ≥98% (HPLC), solid

Sigma-Aldrich

J4455

JSH-23

≥98% (HPLC), solid

PD 98,059 solid

Sigma-Aldrich

P215

PD 98,059

solid

InSolution NF-κB Activation Inhibitor - Calbiochem The InSolution NF-κB Activation Inhibitor controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

481407

InSolution NF-κB Activation Inhibitor - Calbiochem

The InSolution NF-κB Activation Inhibitor controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.

Sigma-Aldrich

614316

TLR4 抑制剂，TAK-242-CAS 243984-11-4-Calbiochem

TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white

溶解性

DMSO: >20 mg/mL
H2O: insoluble

SMILES string

Cc1ccc(cc1)S(=O)(=O)\C=C\C#N

InChI

1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

InChI key

DOEWDSDBFRHVAP-KRXBUXKQSA-N

应用

Bay 11-7082已用作：
  • 细胞核因子kappa B(NF-kB)抑制剂，验证NF-kB信号通路在白介素(IL)-8产生中的作用
  • 核因子kappa B(NF-kB)抑制剂，研究NF-kB活化在猪鼻支原体诱导上皮-间充质转化(EMT)和细胞迁移中的作用
  • NOD样受体热蛋白结构域相关蛋白3(NLRP3)选择性抑制剂，研究其对造血干细胞移植小鼠的肝脏炎症的作用

包装

10 mg in glass bottle

生化/生理作用

Bay 11-7082可作为NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎性小体信号通路的选择性抑制剂。除了抑制核因子-kappa B(NF-kB)之外，Bay 11-7082还可诱发无核红细胞、人类T细胞白血病病毒I型(HTLV-I)感染T细胞系和原代成人T细胞白血病细胞的凋亡。
Bay 11-7082 是细胞因子诱导的 IκB-α 磷酸化的抑制剂。

特点和优势

该化合物是基因调控研究的特色产品。点击此处查看更多特色基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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