B7684

Sigma-Aldrich

Monoclonal Anti-Breast Cancer Resistance Protein antibody produced in mouse

250 μg/mL, clone BXP-34, tissue culture supernatant, aqueous solution

别名:
Anti-BCRP, Anti-ABCG2
MDL number:
NACRES:
NA.41

Quality Level

biological source

mouse

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

BXP-34, monoclonal

form

aqueous solution

mol wt

antigen ~70 kDa

species reactivity

human

concentration

250 μg/mL

application(s)

immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable)
immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections

isotype

IgG1

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... ABCG2(9429)

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Specificity

Reacts with an internal epitope of BCRP. Does not react with the human MDR1, MRP1, MRP2, MRP5 gene products.

Immunogen

mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR.

Physical form

Solution in serum-free culture medium containing 1% bovine serum albumin and 0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

分析证书
原产地证书 (CofO)
G L Scheffer et al.
Cancer research, 60(10), 2589-2593 (2000-05-29)
Tumor cells may display a multidrug resistant phenotype by overexpression of ATP-binding cassette transporters such as multidrug resistance (MDRI) P-glycoprotein, multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP). The presence of BCRP has thus far been reported...
L A Doyle et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(26), 15665-15670 (1998-12-23)
MCF-7/AdrVp is a multidrug-resistant human breast cancer subline that displays an ATP-dependent reduction in the intracellular accumulation of anthracycline anticancer drugs in the absence of overexpression of known multidrug resistance transporters such as P glycoprotein or the multidrug resistance protein....
G L Scheffer et al.
Cancer research, 60(18), 5269-5277 (2000-10-04)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp...
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