Merck

B7880

Sigma-Aldrich

8-溴腺苷-3',5'-环单磷酸 钠盐

≥97% (HPLC), powder

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别名:
8-Br-cAMP
经验公式(希尔记法):
C10H10BrN5NaO6P
CAS号:
分子量:
430.08
Beilstein:
7739743
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥97% (HPLC)

形式

powder

颜色

off-white

溶解性

H2O: 100 mg/mL

储存温度

−20°C

SMILES string

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12

InChI

1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

InChI key

DMRMZQATXPQOTP-GWTDSMLYSA-M

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此商品
B5386B1381D0260
vibrant-m

B7880

8-溴腺苷-3',5'-环单磷酸 钠盐

vibrant-m

B5386

8-溴腺苷-3',5'-环单磷酸

form

powder

form

powder

form

powder

form

powder

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

color

off-white

color

-

color

-

color

white

solubility

H2O: 100 mg/mL

solubility

aqueous base: soluble, clear

solubility

H2O: 50 mg/mL

solubility

H2O: 100 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

一般描述

8-溴腺苷3′,5′-环单磷酸是溴化环单核苷酸。

应用

8-溴腺苷3′,5′-环单磷酸钠盐用于:
  • 研究其对牛黄体中期细胞fas和caspase-3 mRNA表达以及P4产量的影响
  • 用于治疗绒毛膜癌BeWo细胞系,研究其对细胞活力,细胞凋亡和细胞核形态变化的影响
  • 在灌注介质中刺激头肾

生化/生理作用

比 cAMP 更抗磷酸二酯酶水解的细胞通透性 cAMP 类似物。激活培养细胞的蛋白激酶 A、抑制生长、减少增殖、增加分化并诱导凋亡。

特点和优势

该化合物是环核苷酸研究的特色产品。点击此处查看更多特色环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm

其他说明

膜渗透性 cAMP 类似物。

注意

对光和水分敏感。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Chen Y, et al.
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Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely contribute to the highly dynamic processes at the
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Mitogen-activated protein kinase phosphatase 1 (MKP-1) expression is induced by inflammatory factors, and it is an endogenous suppressor of inflammatory response. MKP-1 expression is increased by PDE4 inhibitor rolipram suggesting that it is regulated by cAMP-enhancing compounds. Therefore, we investigated

商品

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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