Merck
All Photos(1)

B8063

Sigma-Aldrich

BML-210

≥98% (HPLC), powder

Synonym(s):
N1-(2-aminophenyl)-N8-phenyl-octanediamide
Empirical Formula (Hill Notation):
C20H25N3O2
CAS Number:
Molecular Weight:
339.43
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to very faintly yellow

溶解性

DMSO: >20 mg/mL

储存温度

2-8°C

SMILES string

Nc1ccccc1NC(=O)CCCCCCC(=O)Nc2ccccc2

InChI

1S/C20H25N3O2/c21-17-12-8-9-13-18(17)23-20(25)15-7-2-1-6-14-19(24)22-16-10-4-3-5-11-16/h3-5,8-13H,1-2,6-7,14-15,21H2,(H,22,24)(H,23,25)

InChI key

RFLHBLWLFUFFDZ-UHFFFAOYSA-N

包装

5, 25 mg in glass bottle

生化/生理作用

BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.
BML-210 is a histone deacetylase inhibitor. Treatment of A549 cells with BML-210 results in a dose-dependent increase in acetylated histone levels (EC50 = 36 μM). In HeLa extracts, the IC50 for inhibition of HDAC activity is 80 μM.

特点和优势

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危险声明

危险分类

Aquatic Chronic 4

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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