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Merck

C2313

Sigma-Aldrich

化合物 48/80

powder,  hypotensive agent

别名:

Poly-p-methoxyphenethylmethylamine

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About This Item

分類程式碼代碼:
41106300
NACRES:
NA.77

产品名称

化合物 48/80,

形狀

powder

品質等級

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

一般說明

化合物48/80,是一种N-甲基p-甲氧基苯乙基胺和甲醛缩合产物。

應用

48/80化合物可用来:
  • 刺激血细胞释放组胺,从而通过ELISA和流式细胞仪测定
  • 诱发肥大细胞脱粒
  • 诱发小鼠过敏性活动、皮炎、瘙痒和炎症

生化/生理作用

化合物48/80是一种低血压药,促进组胺释放。C 48/80降低了 Styela plicata血细胞的吞噬能力。C 48/80 促进肥大细胞脱粒。它抑制钙调蛋白,磷脂酶C,内质网(ER)Ca2+磷酸酶和激活G蛋白。

準備報告

N-甲基-p-甲氧基苯乙基胺和甲醛缩合产物。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)
Histamine regulates the inflammatory response of the tunicate Styela plicata
Garcia-Garcia E, et al.
Developmental and Comparative Immunology, 46(2), 382-391 (2014)
C Bronner et al.
Biochimica et biophysica acta, 920(3), 301-305 (1987-08-15)
Compound 48/80 inhibited phosphatidylinositol-specific phospholipase C activity from human platelets. Whereas 1 microgram/ml of compound 48/80 slightly stimulated Ca2+-dependent phospholipase A2, higher concentrations led to dose-dependent inhibition of this platelet enzyme. This biphasic effect was confirmed with phospholipases A2 purified
Radhika Palkar et al.
The Journal of investigative dermatology, 138(6), 1391-1399 (2017-12-31)
Cooling or the application of mentholated liniments to the skin has been used to treat itch for centuries, yet remarkably little is known about how counter-stimuli such as these induce itch relief. Indeed, there is no clear consensus in the
Antiallergic activity of Aristolochia bracteolata Lank in animal model
Chitme HR, et al.
Indian Journal of Experimental Biology, 48, 46-52 (2010)

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