C2401

Sigma-Aldrich

单响尾蛇毒蛋白

别名:
野百合碱
Empirical Formula (Hill Notation):
C16H23NO6
CAS号:
分子量:
325.36
Beilstein/REAXYS Number:
48732
MDL number:
PubChem Substance ID:
NACRES:
NA.77

mp

204 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3

InChI

1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1

InChI key

QVCMHGGNRFRMAD-XFGHUUIASA-N

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General description

野百合碱是属于吡咯烷嗪生物碱家族的大环化合物。这种成分在猪屎豆中天然存在。

Application

野百合碱已用于盐酸(HCl)注射液中,通过注入实验动物诱发肺动脉高压。

Packaging

1 g in glass bottle
500 mg in glass bottle

Biochem/physiol Actions

野百合碱可诱发大鼠肺血管综合征。这种成分具有公认毒性,可导致肝硬化、肝脏肿大、窦房结综合征和右心室肥大。

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 1544PSN1 6.1 / PGIII

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
Gunaydin S, et al.
Cardiovascular Surgery (London, England), 10(2), 138-145 (2002)
Blockade of frontocortical-brain stem pathway prevents ventricular fibrillation of ischemic heart
Skinner JE and Reed JC
American Journal of Physiology. Heart and Circulatory Physiology, 240(2), H156-H163 (1981)
François Potus et al.
Circulation, 132(10), 932-943 (2015-07-15)
Right ventricular (RV) failure is the most important factor of both morbidity and mortality in pulmonary arterial hypertension (PAH). However, the underlying mechanisms resulting in the failed RV in PAH remain unknown. There is growing evidence that angiogenesis and microRNAs...
Superiority of desflurane over sevoflurane and isoflurane in the presence of pressure-overload right ventricle hypertrophy in rats
Blaudszun G and Morel DR
Anesthesiology, 117(5), 1051-1061 (2012)
Satoshi Matsuo et al.
The Journal of thoracic and cardiovascular surgery, 149(3), 902-909 (2014-12-03)
Lung ischemia-reperfusion (IR) injury during cardiopulmonary surgery is associated with postoperative morbidity and mortality, particularly in patients with pulmonary hypertension (PH). Using a rat model for monocrotaline-induced PH, we investigated the protective effect of rosuvastatin against IR injury in lungs...

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