C2401

Sigma-Aldrich

单响尾蛇毒蛋白

别名:
野百合碱
Empirical Formula (Hill Notation):
C16H23NO6
CAS号:
分子量:
325.36
Beilstein/REAXYS Number:
48732
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

mp

204 °C (dec.) (lit.)

储存温度

2-8°C

SMILES string

[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3

InChI

1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1

InChI key

QVCMHGGNRFRMAD-XFGHUUIASA-N

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一般描述

野百合碱是属于吡咯烷嗪生物碱家族的大环化合物。这种成分在猪屎豆中天然存在。

应用

野百合碱已用于盐酸(HCl)注射液中,通过注入实验动物诱发肺动脉高压。

包装

1 g in glass bottle
500 mg in glass bottle

生化/生理作用

野百合碱可诱发大鼠肺血管综合征。这种成分具有公认毒性,可导致肝硬化、肝脏肿大、窦房结综合征和右心室肥大。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险声明

预防措施声明

hazcat

Acute Tox. 3 Oral - Carc. 2

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

分析证书

原产地证书 (CofO)

The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
Gunaydin S, et al.
Cardiovascular Surgery (London, England), 10(2), 138-145 (2002)
Blockade of frontocortical-brain stem pathway prevents ventricular fibrillation of ischemic heart
Skinner JE and Reed JC
American Journal of Physiology. Heart and Circulatory Physiology, 240(2), H156-H163 (1981)
Martin Connolly et al.
PloS one, 15(2), e0229409-e0229409 (2020-02-29)
The microRNA miR-1 is an important regulator of muscle phenotype including cardiac muscle. Down-regulation of miR-1 has been shown to occur in left ventricular hypertrophy but its contribution to right ventricular hypertrophy in pulmonary arterial hypertension are not known. Previous...
Superiority of desflurane over sevoflurane and isoflurane in the presence of pressure-overload right ventricle hypertrophy in rats
Blaudszun G and Morel DR
Anesthesiology, 117(5), 1051-1061 (2012)
Zhongkai Zhu et al.
Pulmonary circulation, 10(3), 2045894020922129-2045894020922129 (2020-09-15)
Pulmonary hypertension is a chronic vascular disease characterized by pulmonary vasoconstriction and pulmonary arterial remodeling. Pulmonary arterial remodeling is mainly due to small pulmonary arterial wall thickening and lumen occlusion. Previous studies have described intravascular changes in lung sections using...

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