所有图片(2)

C2505

Sigma-Aldrich

肾上腺酮

≥92%

别名:
11β,21-二羟基孕酮, 皮质甾酮, 可的松, 皮质酮, 11β,21-二羟基-孕烯-3,20-酮
Empirical Formula (Hill Notation):
C21H30O4
CAS号:
分子量:
346.46
Beilstein:
2339601
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

200

生物来源

synthetic (organic)

测定

≥92%

形式

powder

mp

179-183 °C (lit.)

溶解性

chloroform: 50 mg/mL, clear, colorless to faintly yellow

运输

ambient

储存温度

room temp

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Gene Information

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应用

Corticosterone has been used:
  • in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
  • as a stress inducing hormone in pregnant mice
  • to test its effect on depression-related behaviors in mice

包装

500 mg in glass bottle

生化/生理作用

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.
Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease
Dufour BD and McBride JL
Experimental neurology, 283(9), 308-317 (2016)
Chronic stress alters concentrations of corticosterone receptors in a tissue-specific manner in wild house sparrows (Passer domesticus)
Lattin CR and Romero LM
The Journal of Experimental Biology, 217(14), 2601-2608 (2014)
Amy E M Newman et al.
The Journal of comparative neurology, 518(18), 3662-3678 (2010-07-24)
Chronic elevations in glucocorticoids can decrease the production and survival of new cells in the adult brain. In rat hippocampus, supraphysiological doses of dehydroepiandrosterone (DHEA; a sex steroid precursor synthesized in the gonads, adrenals, and brain) have antiglucocorticoid properties. With
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin LC and Sibille E
Molecular Psychiatry, 20(3), 377-377 (2015)
Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)

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