Merck
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文件

C2615

Sigma-Aldrich

色原烷醇293B

≥98% (HPLC), powder

所有图片(1)
别名:
反式-N-[6-氰基-3,4-二氢-3-羟基-2,2-二甲基-2H-1-苯并吡喃-4-基]-N-甲基-乙磺酰胺
Empirical Formula (Hill Notation):
C15H20N2O4S
CAS号:
163163-23-3
分子量:
324.40
MDL编号:
MFCD06798368
PubChem化学物质编号:
329775012
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white

溶解性

DMSO: 18 mg/mL

储存温度

−20°C

SMILES string

CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C#N

InChI

1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1

InChI key

HVSJHHXUORMCGK-UONOGXRCSA-N

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此商品
C1055SML2607SML2718
Chromanol 293B ≥98% (HPLC), powder

Sigma-Aldrich

C2615

色原烷醇293B

Cromakalim

Sigma-Aldrich

C1055

Cromakalim

Clevidipine Butyrate ≥98% (HPLC)

Sigma-Aldrich

SML2607

Clevidipine Butyrate

GSK503 ≥98% (HPLC)

Sigma-Aldrich

SML2718

GSK503

form

powder

form

powder

form

powder

form

powder

color

white

color

-

color

white to beige

color

white to beige

solubility

DMSO: 18 mg/mL

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

100

一般描述

色原烷醇293B对映体是钾通道蛋白（KvLQT1）的一种有效抑制剂。在人心房肌细胞中，色原烷醇293B可抑制复极钾电流。色原烷醇293B可通过调节钾电压门控通道（KCNQ1）而改善胰腺中葡萄糖刺激的胰岛素分泌（GSIS）。

应用

色原烷醇293B已用于抑制人上皮细胞系中钙和环腺苷一磷酸（cAMP）激活的钾通道。色原烷醇293B已用于心肌细胞的膜片钳电生理学研究。

生化/生理作用

通过KCNQ1通道阻断慢延迟整流器K+流

特点和优势

该化合物出现在受体分类和信号转导手册的钾离子通道页。欲浏览其他手册页，点击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 + H312 + H332

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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利多卡因

Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulated insulin secretion and increases glucagon-like peptide-1 level in mice
Liu L, et al.
Islets, 6(4), e962386-e962386 (2014)
Effects of chromanol 293B on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes
Du XL, et al.
Journal of Molecular and Cellular Cardiology, 35(3), 293-300 (2003)
Akihiro Inagaki et al.
Pflugers Archiv : European journal of physiology, 471(2), 313-327 (2018-09-27)
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are synthesized from dietary carbohydrates by colonic bacterial fermentation. These SCFAs supply energy, suppress cancer, and affect ion transport. However, their roles in ion transport and regulation in the intracellular
C Lengyel et al.
British journal of pharmacology, 132(1), 101-110 (2001-01-13)
1. The effects of I(Ks) block by chromanol 293B and L-735,821 on rabbit QT-interval, action potential duration (APD), and membrane current were compared to those of E-4031, a recognized I(Kr) blocker. Measurements were made in rabbit Langendorff-perfused whole hearts, isolated
A Varro et al.
The Journal of physiology, 523 Pt 1, 67-81 (2000-02-16)
1. The relative contributions of the rapid and slow components of the delayed rectifier potassium current (IKr and IKs, respectively) to dog cardiac action potential configuration were compared in ventricular myocytes and in multicellular right ventricular papillary muscle and Purkinje
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