C2806

Sigma-Aldrich

人降钙素基因相关肽片段 8-37

≥97% (HPLC), powder

别名:
α-CGRP 8-37, FB 人
Empirical Formula (Hill Notation):
C139H230N44O38
CAS号:
分子量:
3125.59
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

质量水平

200

测定

≥97% (HPLC)

形式

powder

组成

Peptide content, ~70%

UniProt登记号

储存温度

−20°C

SMILES string

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

InChI

1S/C139H230N44O38/c1-66(2)48-86(161-102(193)60-155-113(197)74(17)159-120(204)87(49-67(3)4)168-118(202)83(40-31-45-152-138(147)148)163-123(207)90(53-80-57-151-65-158-80)173-136(220)111(77(20)188)182-131(215)105(145)69(7)8)121(205)169-88(50-68(5)6)122(206)176-96(64-186)129(213)165-84(41-32-46-153-139(149)150)119(203)175-94(62-184)115(199)156-58-101(192)154-59-104(195)177-107(71(11)12)134(218)179-108(72(13)14)133(217)166-82(39-28-30-44-141)117(201)171-91(54-98(142)189)125(209)172-92(55-99(143)190)124(208)170-89(52-79-36-25-22-26-37-79)126(210)180-109(73(15)16)137(221)183-47-33-42-97(183)130(214)181-110(76(19)187)135(219)174-93(56-100(144)191)127(211)178-106(70(9)10)132(216)157-61-103(194)162-95(63-185)128(212)164-81(38-27-29-43-140)116(200)160-75(18)114(198)167-85(112(146)196)51-78-34-23-21-24-35-78/h21-26,34-37,57,65-77,81-97,105-111,184-188H,27-33,38-56,58-64,140-141,145H2,1-20H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,146,196)(H,151,158)(H,154,192)(H,155,197)(H,156,199)(H,157,216)(H,159,204)(H,160,200)(H,161,193)(H,162,194)(H,163,207)(H,164,212)(H,165,213)(H,166,217)(H,167,198)(H,168,202)(H,169,205)(H,170,208)(H,171,201)(H,172,209)(H,173,220)(H,174,219)(H,175,203)(H,176,206)(H,177,195)(H,178,211)(H,179,218)(H,180,210)(H,181,214)(H,182,215)(H4,147,148,152)(H4,149,150,153)/t74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,105-,106-,107-,108-,109-,110-,111-/m0/s1

InChI key

NDACAFBDTQIYCQ-YVQXRMNASA-N

Gene Information

human ... CALCA(796)

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Amino Acid Sequence

Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2

一般描述

降钙素相关肽 α(CALCA) 是由 37 个氨基酸组成的血管活性神经肽。散在分布于中枢和外周神经系统。降钙素/降钙素基因相关肽基因复合物编码一个小的肽家族:降钙素、katacalcin 和 CALCA。这种血管扩张剂比其他血管扩张剂强效,如腺苷、P 物质或乙酰胆碱。CALCA 基因位于人类染色体 11p15.2-p15.1降钙素原 (PCT) 是一种降钙素 (CT) 前体。

应用

降钙素基因相关肽片段 8-37 人已用于给药。已被用于测试降钙素基因相关肽 (CGRP) 通过影响交感神经流出在胎儿心血管和代谢防御反应中对急性低氧血症角色的假设。

生化/生理作用

CGRP 受体的选择性竞争性拮抗剂,而非降钙素受体。
降钙素基因相关肽 (CALCA) 是一种促血管生长因子,在人类胎盘发育中起重要作用。CALCA 基因突变与帕金森病的关系的疾病,卵巢癌和原发性高血压。钙诱导血管内皮细胞增殖、迁移和毛细血管样管形成。

其他说明

从0.1%TFA水溶液中冻干

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

原产地证书 (CofO)

Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development
Dong Y L, et al.
Biology of Reproduction, 76(5), 892-899 (2007)
Saurabh Gupta et al.
British journal of pharmacology, 161(8), 1885-1898 (2010-09-02)
Calcitonin gene-related peptide (CGRP) is widely distributed in the trigeminovascular system and released from sensory fibres of the cranial dura mater upon noxious stimulation. Such release may be a mechanism underlying migraine headache. Based on data from guinea pig basilar...
Phillip Edward Kunkler et al.
Pain, 152(1), 38-44 (2010-11-16)
The TRPA1 receptor is a member of the transient receptor potential (TRP) family of ion channels expressed in nociceptive neurons. TRPA1 receptors are targeted by pungent compounds from mustard and garlic and environmental irritants such as formaldehyde and acrolein. Ingestion...
Ana Luísa Pires et al.
American journal of physiology. Heart and circulatory physiology, 302(5), H1131-H1137 (2012-01-10)
Intermedin (IMD) is a novel vasoactive peptide from the calcitonin gene-related peptide (CGRP) implicated in cardiac regulation, yet the contractile effects of IMD remain controversial, since previous studies in vivo and isolated cardiomyocytes documented contradictory results. We hypothesized cardiac endothelial...
Calcitonin gene-related peptide antagonism attenuates the haemodynamic and glycaemic responses to acute hypoxaemia in the late gestation sheep fetus
Thakor A S, et al.
The Journal of Physiology, 566(2), 587-597 (2005)

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