C2970

Monoclonal Anti-Cathepsin L antibody produced in mouse

clone 33/2, ascites fluid

• Synonym(s): Anti-CATL, Anti-CTSL, Anti-MEP
• MDL编号: MFCD01321805
• NACRES: NA.41

Properties

• 生物来源: mouse
• 质量水平: 200
• 偶联物: unconjugated
• 抗体形式: ascites fluid
• antibody product type: primary antibodies
• 克隆: 33/2, monoclonal
• 分子量: antigen (human cathepsin L) 25 kDa; antigen (human procathepsin L) 42 kDa
• 包含: 15 mM sodium azide
• species reactivity: mouse, mink, human, rat
• technique(s): immunohistochemistry (frozen sections): suitable; indirect ELISA: suitable; microarray: suitable; western blot: 1:200 using whole cell extract of a cultured mink lung cell line
• 同位素/亚型: IgG1
• UniProt登记号: P07711
• 运输: dry ice
• 储存温度: −20°C
• Gene Information: human ... CTSL1(1514) ; mouse ... Ctsl(13039) ; rat ... Ctsl1(25697)

Description

一般描述

Cathepsin L is a cysteine protease and is secreted by numerous transformed cells in its inactive pre-form.[1] It is ubiquitously expressed and is localized in nucleus. Cathepsin L have substrate interacting region located in L and R domain loops.[2]

特异性

Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for the suppression of the malignant growth of myeloma cells. Cross-reactivity is observed with rat cathepsin L (strong), mouse procathepsin L (weak) and mink cathepsin and procathepsin L. Does not cross-react with human cathepsin types B, D, H and S, procathepsins B and D, rat cathepsin B, and mouse procathepsins B and D.

免疫原

procathepsin L isolated from the human lung cancer cell line EPLC 32M1.

生化/生理作用

Cathepsin L expression is correlated with the metastatic potential of transformed cells.[3] Cathepsin L is capable of degrading protein constituents of the extracellular matrix, this enzyme is thought to play a crucial role in tumor progression, metastasis and other disorders where the destruction of the matrix is the major cause of disease.[4]

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: nwg
• 闪点(F): Not applicable
• 闪点(C): Not applicable