Merck
All Photos(2)

C2970

Sigma-Aldrich

Monoclonal Anti-Cathepsin L antibody produced in mouse

clone 33/2, ascites fluid

Synonym(s):
Anti-CATL, Anti-CTSL, Anti-MEP
MDL编号:
NACRES:
NA.41

生物来源

mouse

质量水平

200

偶联物

unconjugated

抗体形式

ascites fluid

antibody product type

primary antibodies

克隆

33/2, monoclonal

分子量

antigen (human cathepsin L) 25 kDa
antigen (human procathepsin L) 42 kDa

包含

15 mM sodium azide

species reactivity

mouse, mink, human, rat

technique(s)

immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:200 using whole cell extract of a cultured mink lung cell line

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

Gene Information

human ... CTSL1(1514)
mouse ... Ctsl(13039)
rat ... Ctsl1(25697)

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一般描述

Cathepsin L is a cysteine protease and is secreted by numerous transformed cells in its inactive pre-form.[1] It is ubiquitously expressed and is localized in nucleus. Cathepsin L have substrate interacting region located in L and R domain loops.[2]

特异性

Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for the suppression of the malignant growth of myeloma cells. Cross-reactivity is observed with rat cathepsin L (strong), mouse procathepsin L (weak) and mink cathepsin and procathepsin L. Does not cross-react with human cathepsin types B, D, H and S, procathepsins B and D, rat cathepsin B, and mouse procathepsins B and D.

免疫原

procathepsin L isolated from the human lung cancer cell line EPLC 32M1.

生化/生理作用

Cathepsin L expression is correlated with the metastatic potential of transformed cells.[3] Cathepsin L is capable of degrading protein constituents of the extracellular matrix, this enzyme is thought to play a crucial role in tumor progression, metastasis and other disorders where the destruction of the matrix is the major cause of disease.[4]

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(F)

Not applicable

闪点(C)

Not applicable

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