Merck

C3912

Sigma-Aldrich

8-(4-氯苯硫基)-鸟苷 3′,5′-环单磷酸 钠盐

≥97.0% (HPLC), powder

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别名:
pCPT-cAMP
Empirical Formula (Hill Notation):
C16H14ClN5NaO6PS
CAS号:
分子量:
493.79
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥97.0% (HPLC)

形式

powder

颜色

white

溶解性

H2O: 25 mg/mL

储存温度

−20°C

SMILES string

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

InChI

1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1

InChI key

YIJFVHMIFGLKQL-DNBRLMRSSA-M

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此商品
C0735C5438A6885
form

powder

form

solid

form

powder

form

powder

color

white

color

-

color

white

color

white

solubility

H2O: 25 mg/mL

solubility

-

solubility

H2O: 25 mg/mL

solubility

H2O: 10 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

应用

8-(4-硫代氯苯基)腺苷3′5′-环状-单磷酸钠盐用于:
  • 上调细胞胆固醇泵(三磷酸腺苷(ATP)结合盒(ABC)转运蛋白1,ABCA-1)
  • 葡萄糖生成测定
  • 刺激气道上皮细胞的囊性纤维化跨膜传导调节因子(CFTR)通道

生化/生理作用

膜通透性 cAMP 类似物。用作 cAMP 依赖性蛋白激酶 (PKA) 的选择性激活剂。抑制 cGMP 依赖性磷酸二酯酶,在较高浓度时,抑制 cAMP 依赖性磷酸二酯酶。抑制 n-甲酰-Met-Leu-Phe 刺激的磷酸肌醇水解和分泌,但不抑制白细胞中的血小板活化因子。使 HL-60 细胞更能抵抗 NO 诱导的 DNA 损伤。

特点和优势

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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商品

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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