所有图片(3)
About This Item
经验公式（希尔记法）:
C21H36N7O16P3S · xH2O
CAS号:
分子量:
767.53 (anhydrous basis)
Beilstein:
77809
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21
推荐产品
生物源
yeast
品質等級
化驗
≥85% (UV, HPLC)
形狀
powder
官能基
phospholipid
運輸包裝
ambient
儲存溫度
−70°C
SMILES 字串
O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1
InChI 密鑰
TVSAELAFGDOPKI-BLPRJPCASA-N
應用
辅酶A水合物已用于中华绒螯蟹体内重组乙酰乙酰辅酶A硫解酶（rACAT）的硫解酶测定。它可以用作拉曼光谱测定中的参考标准品。
生化／生理作用
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。CoA在许多代谢途径中起重要作用，包括三羧酸循环，以及脂肪酸的合成和氧化。CoA的主要功能之一是酰基的携带和转移。酰化衍生物，例如乙酰-CoA，是许多代谢反应中的关键中间体。在饥饿期间以及癌症、糖尿病和酗酒等条件下，CoA水平可能会发生变化。
注意
游离酸不如钠盐或锂盐稳定；在−80 °C下储存时，6个月内会发生5％的分解。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Francis McCoy et al.
Molecular cell, 52(3), 325-339 (2013-10-08)
Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus
Takuya Ishibashi et al.
Extremophiles : life under extreme conditions, 16(6), 819-828 (2012-09-04)
We have previously reported that the majority of the archaea utilize a novel pathway for coenzyme A biosynthesis (CoA). Bacteria/eukaryotes commonly use pantothenate synthetase and pantothenate kinase to convert pantoate to 4'-phosphopantothenate. However, in the hyperthermophilic archaeon Thermococcus kodakarensis, two
Gregory R Wagner et al.
The Journal of biological chemistry, 288(40), 29036-29045 (2013-08-16)
Alterations in mitochondrial protein acetylation are implicated in the pathophysiology of diabetes, the metabolic syndrome, mitochondrial disorders, and cancer. However, a viable mechanism responsible for the widespread acetylation in mitochondria remains unknown. Here, we demonstrate that the physiologic pH and
Rajesh K Harijan et al.
The Biochemical journal, 455(1), 119-130 (2013-08-06)
Thiolases are essential CoA-dependent enzymes in lipid metabolism. In the present study we report the crystal structures of trypanosomal and leishmanial SCP2 (sterol carrier protein, type-2)-thiolases. Trypanosomatidae cause various widespread devastating (sub)-tropical diseases, for which adequate treatment is lacking. The
Haruyuki Atomi et al.
Biochemical Society transactions, 41(1), 427-431 (2013-01-30)
CoA is a ubiquitous molecule in all three domains of life and is involved in various metabolic pathways. The enzymes and reactions involved in CoA biosynthesis in eukaryotes and bacteria have been identified. By contrast, the proteins/genes involved in CoA
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