所有图片(3)

C4282

辅酶 A 水合物

≥85% (UV, HPLC)

所有图片(3)

别名:

CoA

Empirical Formula (Hill Notation):

C₂₁H₃₆N₇O₁₆P₃S · xH₂O

CAS号:

85-61-0

分子量:

767.53 (anhydrous basis)

Beilstein:

77809

MDL编号:

MFCD06795839

PubChem化学物质编号:

24892684

NACRES:

NA.21

生物来源

yeast

测定

≥85% (UV, HPLC)

形式

powder

官能团

phospholipid

运输

ambient

储存温度

−20°C

SMILES string

O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS

InChI

1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1

InChI key

TVSAELAFGDOPKI-BLPRJPCASA-N

应用

辅酶A水合物已用于中华绒螯蟹体内重组乙酰乙酰辅酶A硫解酶（rACAT）的硫解酶测定。它可以用作拉曼光谱测定中的参考标准品。

包装

10 mg in glass bottle

25, 100 mg in poly bottle

生化/生理作用

辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。CoA在许多代谢途径中起重要作用，包括三羧酸循环，以及脂肪酸的合成和氧化。CoA的主要功能之一是酰基的携带和转移。酰化衍生物，例如乙酰-CoA，是许多代谢反应中的关键中间体。在饥饿期间以及癌症、糖尿病和酗酒等条件下，CoA水平可能会发生变化。

注意

游离酸不如钠盐或锂盐稳定；在−20 °C下储存时，6个月内会发生5％的分解。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

请输入批号搜索分析证书（COA）。

原产地证书 (CofO)

请输入批号搜索原产地证书（COO）。

Quotes and Ordering

Bulk Quote-Order Product

Metabolic activation of CaMKII by coenzyme A.

Francis McCoy et al.

Molecular cell, 52(3), 325-339 (2013-10-08)

Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus

A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea.

Takuya Ishibashi et al.

Extremophiles : life under extreme conditions, 16(6), 819-828 (2012-09-04)

We have previously reported that the majority of the archaea utilize a novel pathway for coenzyme A biosynthesis (CoA). Bacteria/eukaryotes commonly use pantothenate synthetase and pantothenate kinase to convert pantoate to 4'-phosphopantothenate. However, in the hyperthermophilic archaeon Thermococcus kodakarensis, two

Structural basis for a bispecific NADP+ and CoA binding site in an archaeal malonyl-coenzyme A reductase.

Ulrike Demmer et al.

The Journal of biological chemistry, 288(9), 6363-6370 (2013-01-18)

Autotrophic members of the Sulfolobales (crenarchaeota) use the 3-hydroxypropionate/4-hydroxybutyrate cycle to assimilate CO2 into cell material. The product of the initial acetyl-CoA carboxylation with CO2, malonyl-CoA, is further reduced to malonic semialdehyde by an NADPH-dependent malonyl-CoA reductase (MCR); the enzyme

CoA biosynthesis in archaea.

Haruyuki Atomi et al.

Biochemical Society transactions, 41(1), 427-431 (2013-01-30)

CoA is a ubiquitous molecule in all three domains of life and is involved in various metabolic pathways. The enzymes and reactions involved in CoA biosynthesis in eukaryotes and bacteria have been identified. By contrast, the proteins/genes involved in CoA

Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop.

Rajesh K Harijan et al.

The Biochemical journal, 455(1), 119-130 (2013-08-06)

Thiolases are essential CoA-dependent enzymes in lipid metabolism. In the present study we report the crystal structures of trypanosomal and leishmanial SCP2 (sterol carrier protein, type-2)-thiolases. Trypanosomatidae cause various widespread devastating (sub)-tropical diseases, for which adequate treatment is lacking. The

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