Merck

C4396

Sigma-Aldrich

碳酸酐酶I 来源于人类红细胞

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别名:
碳酸盐脱水酶, 碳酸酐酶同工酶I, 碳酸酯水解酶
CAS号:
EC 号:
MDL编号:

形式

powder

specific activity

100-500 W-A units/mg protein

分子量

30 kDa

颜色

white

pI 

~6.6

UniProt登记号

储存温度

−20°C

Gene Information

human ... CA1(759)

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此商品
C6653C2624C3934
specific activity

100-500 W-A units/mg protein

specific activity

-

specific activity

≥3,500 W-A units/mg protein

specific activity

≥2,000 W-A units/mg protein

mol wt

30 kDa

mol wt

-

mol wt

-

mol wt

30 kDa

color

white

color

-

color

-

color

-

UniProt accession no.

P00915

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

应用

来自人红细胞(HCA)的碳酸酐酶已被用于研究碳酸酐酶(CA)的熔球态。分子伴侣样α-晶状体蛋白能够与这种状态的酶结合并阻止其聚集。 Sigma的酶已被用于分析酶的热力学稳定性。 此外,已经评估了该酶在人非小细胞肺癌中的临床意义。

生化/生理作用

碳酸酐酶是一种锌金属酶,其分子量约为30,000Da。该酶可以催化二氧化碳的水合,形成碳酸。它参与一些重要过程,如pH和CO2稳态、碳酸氢盐和CO2的转运、生物合成反应、骨吸收、钙化和致瘤性。因此,该酶是一个重要的抑制剂靶标,在青光眼、癫痫和帕金森氏病等各种病症中具有临床应用价值。

单位定义

在0 °C条件下,一Wilbur-Anderson (W-A)单位可使0.02M Trizma缓冲液pH在一分钟内从8.3降至 6.3。(一W-A单位基本上相当于一Roughton-Booth单位。)

制备说明

色谱
纯化的。

抑制剂

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable


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其他客户在看

Slide 1 of 7

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Daumantas Matulis et al.
Biochemistry, 44(13), 5258-5266 (2005-03-30)
ThermoFluor (a miniaturized high-throughput protein stability assay) was used to analyze the linkage between protein thermal stability and ligand binding. Equilibrium binding ligands increase protein thermal stability by an amount proportional to the concentration and affinity of the ligand. Binding
K Rajaraman et al.
The Journal of biological chemistry, 271(44), 27595-27600 (1996-11-01)
alpha-Crystallin, a multimeric protein, exhibits chaperone-like activity in preventing aggregation of several proteins. We have studied the chaperone-like activity of alpha-crystallin toward heat-induced aggregation of bovine and human carbonic anhydrase. Human carbonic anhydrase aggregates at 60 degrees C, while bovine
Whei Ling Chiang et al.
Cancer letters, 188(1-2), 199-205 (2002-10-31)
This study was designed to elucidate the possible relationship between the expression of cytosolic carbonic anhydrase (CA) and non-small cell lung cancer (NSCLC). The activity and protein expression patterns of carbonic anhydrase I (CAI) and II (CAII) of 70 NSCLC
Qiang Jin et al.
Biosensors & bioelectronics, 83, 193-199 (2016-04-30)
A near-infrared fluorescent probe (DDAB) for highly selective and sensitive detection of carboxylesterase 2 (CE2) has been designed, synthesized, and systematically studied both in vitro and in vivo. Upon addition of CE2, the ester bond of DDAB could be rapidly
Pavel V Shliaha et al.
Journal of proteome research, 12(6), 2323-2339 (2013-03-22)
qTOF mass spectrometry and traveling wave ion mobility separation (TWIMS) hybrid instruments (q-TWIMS-TOF) have recently become commercially available. Ion mobility separation allows an additional dimension of precursor separation inside the instrument, without incurring an increase in instrument time. We comprehensively

实验方案

Enzymatic Assay of Carbonic Anhydrase for Wilbur-Anderson Units (EC 4.2.1.1)

Objective: To standardize a procedure for the enzymatic assay of Carbonic Anhydrase (EC 4.2.1.1) for Wilbur-Anderson Units.

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