所有图片(1)

C4859

Sigma-Aldrich

放线菌酮 溶液

Ready-Made Solution, microbial, 100 mg/mL in DMSO, 0.2 μm filtered

别名:
CHX
Empirical Formula (Hill Notation):
C15H23NO4
CAS号:
分子量:
281.35
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

300

生物来源

microbial

描述

suitable for testing specifications (CHO C. growth inhibitor)

无菌性

0.2 μm filtered

形式

solution

浓度

100 mg/mL in DMSO

溶解性

DMSO: soluble

作用机制

protein synthesis | interferes

抗生素抗菌谱

fungi
yeast

储存温度

2-8°C

SMILES string

O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

Gene Information

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特异性

经测试可用于细胞生长停滞、选择抗环己酰亚胺的酵母、诱导凋亡、以及促进通过FasL凋亡的诱导。

包装

1 mL in glass bottle

生化/生理作用

环己酰亚胺(CHX)是由灰链霉菌产生的一种抗生素。它的主要生物学活性是真核生物中的翻译抑制,从而导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。

其他说明

保存于密闭容器内,置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。储存类别(TRGS 510): 不可燃,急性毒性1和2类/剧毒有害物质。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(F)

188.6 °F - closed cup

闪点(C)

87 °C - closed cup

分析证书

原产地证书 (CofO)

Konstantinos Boulias et al.
Molecular cell, 75(3), 631-643 (2019-07-08)
mRNAs are regulated by nucleotide modifications that influence their cellular fate. Two of the most abundant modified nucleotides are N6-methyladenosine (m6A), found within mRNAs, and N6,2'-O-dimethyladenosine (m6Am), which is found at the first transcribed nucleotide. Distinguishing these modifications in mapping
Hye-Yeoung Yun et al.
PLoS biology, 17(7), e3000367-e3000367 (2019-07-20)
Human papillomaviruses (HPVs) are causative agents of various diseases associated with cellular hyperproliferation, including cervical cancer, one of the most prevalent tumors in women. E7 is one of the two HPV-encoded oncoproteins and directs recruitment and subsequent degradation of tumor-suppressive
Matthias Rottmann et al.
Science (New York, N.Y.), 329(5996), 1175-1180 (2010-09-04)
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates
Yuh-Shyan Tsai et al.
Oncotarget, 5(15), 6425-6436 (2014-08-15)
Altered DAB2IP gene expression often detected in prostate cancer (PCa) is due to epigenetic silencing. In this study, we unveil a new mechanism leading to the loss of DAB2IP protein; an oncogenic S-phase kinase-associated protein-2 (Skp2) as E3 ubiquitin ligase
Soma Vignarajan et al.
Oncotarget, 5(15), 6289-6299 (2014-07-16)
Aberrant increase in pAKT, due to a gain-of-function mutation of PI3K or loss-of-function mutation or deletion of PTEN, occurs in prostate cancer and is associated with poor patient prognosis. Cytosolic phospholipase A₂α (cPLA₂α) is a lipid modifying enzyme by catalyzing

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