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Merck

C6013

Sigma-Aldrich

胆甾醇半琥珀酸酯 三羟甲基氨基甲烷盐

anionic detergent

别名:

3β-Hydroxy-5-cholestene 3-hemisuccinate, CHEMS, CHS, 胆固醇半琥珀酸酯, 胆甾醇琥珀酸酯

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About This Item

经验公式(希尔记法):
C31H50O4 · C4H11NO3
分子量:
607.86
MDL號碼:
分類程式碼代碼:
12352211
eCl@ss:
39023139
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

化驗

≥98% (TLC)

形狀

powder

官能基

ester

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O

InChI

1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1

InChI 密鑰

SLDYONDUXRBLLR-XTCKSVDZSA-N

應用

胆固醇半琥珀酸酯三盐用于:
  • 制备用于葡聚糖合酶测定的溶解缓冲液
  • 制备用于将阿片受体固定在顺磁珠上的免疫沉淀缓冲液。
  • 作为脂质体和蛋白突触结合蛋白1的膜稳定剂
  • 作为叶酸修饰的自微乳化药物递送系统的组成部分。
  • 与正十二烷基 β-D-麦芽糖苷(DDM)一起用于溶解红细胞血影和趋化因子受体CCR1
  • 用于溶解蛋白

生化/生理作用

胆固醇半琥珀酸盐是一种可电离的阴离子洗涤剂,可稳定大的单层囊泡。这些脂质体囊泡作为抗癌药物、寡核苷酸和抗生素的递送剂。据报道胆固醇琥珀酸酯还具有抗增殖活性,并可以在临床上用作抗肿瘤剂。

準備報告

浓度为1 mg/ml的半琥珀酸胆固醇三盐在甲醇中生成澄清、无色的溶液。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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I M Hafez et al.
Biophysical journal, 79(3), 1438-1446 (2000-09-02)
The pH-dependent fusion properties of large unilamellar vesicles (LUVs) composed of binary mixtures of anionic and cationic lipids have been investigated. It is shown that stable LUVs can be prepared from the ionizable anionic lipid cholesteryl hemisuccinate (CHEMS) and the
Samantha J Allen et al.
Protein expression and purification, 66(1), 73-81 (2009-03-12)
Chemokine receptors are a specific class of G-protein-coupled receptors (GPCRs) that control cell migration associated with routine immune surveillance, inflammation and development. In addition to their roles in normal physiology, these receptors and their ligands are involved in a large
P Mazur et al.
The Journal of biological chemistry, 271(24), 14604-14609 (1996-06-14)
In the yeast Saccharomyces cerevisiae, the family of RHO genes are implicated in the control of morphogenetic events although the molecular targets of these GTP-binding proteins remain largely unknown. The activity of 1,3-beta-D-glucan synthase, the product of which is essential
David Ott et al.
Protein engineering, design & selection : PEDS, 18(3), 153-160 (2005-03-26)
Opioid receptors, like many G protein-coupled receptors (GPCRs), are notoriously unstable in detergents. We have now developed a more stable variant of the mu-opioid receptor (MOR) and also a method for the immobilization of solubilized, functional opioid receptors on a
Tomoko Ohno et al.
Ocular immunology and inflammation, 27(5), 699-705 (2018-11-06)
Purpose: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. Methods: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms

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