所有图片(1)

C6762

细胞松弛素B 来源于Drechslera dematioidea

≥98% (HPLC), powder

所有图片(1)

别名:

Phomin

Empirical Formula (Hill Notation):

C₂₉H₃₇NO₅

CAS号:

14930-96-2

分子量:

479.61

Beilstein:

1096207

EC 号:

239-000-2

MDL编号:

MFCD00077704

PubChem化学物质编号:

24892890

NACRES:

NA.32

质量水平

300

测定

≥98% (HPLC)

形式

powder

颜色

white

溶解性

DMSO: 10 mg/mL

抗生素抗菌谱

fungi

作用机制

DNA synthesis | interferes

储存温度

−20°C

SMILES string

C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O

InChI

1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

InChI key

GBOGMAARMMDZGR-TYHYBEHESA-N

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一般描述

Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:

Disruption of actin filaments and of interaction of actin filaments in solution
Inhibition of actin polymerization
Inhibition of subunit association and dissociation

Cytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.

包装

1, 5, 10, 25, 50 mg in serum bottle

生化/生理作用

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

象形图

GHS06,GHS08

警示用语：

Danger

危险声明

H300 + H310 + H330 - H361

预防措施声明

P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

分析证书

请输入批号搜索分析证书（COA）。

原产地证书 (CofO)

请输入批号搜索原产地证书（COO）。

Product Information Sheet

Product Information Sheet - C6762

Quotes and Ordering

Bulk Quote-Order Product

Effect of temperature during irradiation on the level of micronuclei in human peripheral blood lymphocytes exposed to X-rays and neutrons.

Kinga Brzozowska et al.

International journal of radiation biology, 85(10), 891-899 (2009-07-30)

It has been reported that the level of cytogenetic damage in human peripheral blood lymphocytes (PBL) is higher following irradiation at 37 degrees C than at 0-4 degrees C. The mechanisms of this cytogenetic temperature effect are not fully known.

The yield of radiation-induced micronuclei in early and late-arising binucleated cells depends on radiation quality.

Christian Johannes et al.

Mutation research, 701(1), 80-85 (2010-05-18)

There are conflicting data regarding the effect of culturing time of human peripheral blood lymphocytes on the yield of chromosomal aberrations induced by sparsely ionising radiation in the G0 phase of the cell cycle. While some authors find that the

Chemical, cytotoxic and genotoxic analysis of etidronate in sodium hypochlorite solution.

N V Ballal et al.

International endodontic journal, 52(8), 1228-1234 (2019-03-09)

To test whether the incorporation of a chelation powder, etidronate, marketed for root canal irrigation (Dual Rinse HEDP) into a sodium hypochlorite (NaOCl) solution induced additional cytotoxic and genotoxic effects not observed with NaOCl alone. Fresh and 24-h-old mixtures of

Latrunculin A can improve the birth rate of cloned mice and simplify the nuclear transfer protocol by gently inhibiting actin polymerization.

Yukari Terashita et al.

Biology of reproduction, 86(6), 180-180 (2012-04-12)

Although animal cloning is becoming more practicable, there are many abnormalities in cloned embryos, and the success rate of producing live animals by cloning has been low. Here, we focused on the procedure for preventing pseudo-second polar body extrusion from

Microfluidics-based assessment of cell deformability.

Andrea Adamo et al.

Analytical chemistry, 84(15), 6438-6443 (2012-07-04)

Mechanical properties of cells have been shown to have a significant role in disease, as in many instances cell stiffness changes when a cell is no longer healthy. We present a high-throughput microfluidics-based approach that exploits the connection between travel

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