所有图片(3)

C7698

Sigma-Aldrich

放线菌酮

from microbial, ≥94% (TLC)

别名:
戊二酰亚胺环己酮, 3-[2-(3,5-二甲基-2-氧代环己基)-2-羟乙基]戊二酰亚胺, 奈良霉素 A
Empirical Formula (Hill Notation):
C15H23NO4
CAS号:
分子量:
281.35
Beilstein:
88868
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

200

生物来源

microbial

测定

≥94% (TLC)

形式

powder

溶解性

ethanol: soluble, clear to hazy

作用机制

protein synthesis | interferes

抗生素抗菌谱

fungi
yeast

储存温度

2-8°C

SMILES string

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

Gene Information

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应用

  • In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment.
  • It has been used to inhibit translation in mammalian cells.
  • It has been used to suppress fungal growth.

包装

1, 5 g in poly bottle

生化/生理作用

放线菌酮 (CHX) 是由灰色链霉菌产生的抗生素。它的主要生物活性为真核生物中的翻译抑制,从而导致细胞生长停滞和细胞死亡。CHX 广泛用于选择酵母菌和真菌 CHX 耐药株,可控抑制蛋白合成以检测短寿命蛋白和超高诱导蛋白表达,以及进行凋亡诱导或通过死亡受体促进凋亡诱导。

其他说明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

警示用语:

Danger

危险分类

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

分析证书

原产地证书 (CofO)

Quality control of a transcriptional regulator by SUMO-targeted degradation.
Wang Z and Prelich G
Molecular and Cellular Biology, 29, 1694-1694 (2009)
Nonsense-mediated mRNA decay (NMD) blockage promotes nonsense mRNA stabilization in protein 4.1R deficient cells carrying the 4.1R Coimbra variant of hereditary elliptocytosis.
Moriniere M et al.
Blood Cells, Molecules and Diseases, 45, 284-284 (2010)
Potential pathogenic bacteria in metalworking fluids and aerosols from a machining facility.
Perkins SD and Angenent LT
FEMS Microbiology Ecology, 74, 643-643 (2010)
Junxuan Xu et al.
Biochimica et biophysica acta. Molecular cell research, 1866(9), 1487-1497 (2019-06-24)
Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. In this study, we show that dZIP13 level is strongly regulated by iron. In addition to a mild response to iron
Zhen Zhang et al.
Frontiers in endocrinology, 5, 206-206 (2014-12-19)
O-linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification involving an attachment of a single β-N-acetylglucosamine moiety to serine or threonine residues in nuclear and cytoplasmic proteins. Cellular O-GlcNAc levels are regulated by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which

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