Merck
  • C7698
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C7698

Sigma-Aldrich

环己酰亚胺,大包装

from microbial, ≥94% (TLC)

Synonym(s):
3- [2-(3,5-二甲基-2-氧代环己基)-2-羟乙基]戊二酰亚胺, 放线菌酮, 纳拉霉素A
Empirical Formula (Hill Notation):
C15H23NO4
CAS Number:
Molecular Weight:
281.35
Beilstein:
88868
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

生物来源

microbial

质量水平

检测方案

≥94% (TLC)

形式

powder

溶解性

ethanol: soluble, clear to hazy

抗生素抗菌谱

fungi
yeast

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES string

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

Gene Information

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环己酰亚胺,大包装

assay

≥94% (TLC)

assay

≥90% (HPLC)

assay

≥90% (by assay)

assay

≥95% (HPLC)

form

powder

form

powder or crystals

form

powder

form

-

solubility

ethanol: soluble, clear to hazy

solubility

-

solubility

-

solubility

H2O: slightly soluble

storage temp.

2-8°C

storage temp.

-

storage temp.

10-30°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

biological source

microbial

biological source

microbial

biological source

-

biological source

-

应用

  • 在酵母菌株中,环己酰亚胺已被用作环己酰亚胺追踪实验中的蛋白质合成抑制剂。
  • 它已被用于抑制哺乳动物细胞中的翻译。
  • 它已被用于抑制真菌生长。

生化/生理作用

环己酰亚胺(CHX)是由灰链霉菌产生的一种抗生素。它的主要生物学活性是真核生物中的翻译抑制,从而导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。

其他说明

保存于密闭容器内,置于干燥通风处。置于干燥处保存。

警示用语:

Danger

危险分类

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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