Merck

D0260

Sigma-Aldrich

N6,2′-O-二丁酰基腺苷 3′,5′-环单磷酸 钠盐

≥97% (HPLC), powder

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别名:
二丁酰 cAMP 钠盐, 二丁酰环磷腺苷 钠盐, 布拉地新 钠盐
线性分子式:
C18H23N5O8PNa
CAS号:
分子量:
491.37
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥97% (HPLC)

形式

powder

杂质

≤0.5% cyclic AMP and 2′-O-monobutyryl-cyclic AMP
≤3% N6-monobutyryl-cyclic AMP

颜色

white

溶解性

H2O: 100 mg/mL

储存温度

−20°C

SMILES string

[Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC

InChI

1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1

InChI key

KRBZRVBLIUDQNG-JBVYASIDSA-M

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此商品
D062728745-MSML1228
Cyclic-di-GMP sodium salt ≥98% (HPLC)

Sigma-Aldrich

SML1228

环二鸟苷酸 钠盐

form

powder

form

powder

form

lyophilized solid

form

powder

color

white

color

off-white

color

white

color

white to beige

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

water: 1 mg/mL

solubility

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

impurities

≤0.5% cyclic AMP and 2′-O-monobutyryl-cyclic AMP

impurities

≤0.5% Cyclic AMP, ≤3% monobutyryl derivatives

impurities

-

impurities

-

应用

N6,2′-O-二丁酰基腺苷3′,5′-环磷酸钠盐已用于:
  • 用作神经rest干细胞(NCSCs)分化的培养基补充剂
  • 用作低温保存人iPSC(诱导多能干细胞)分化神经元解冻培养基的成分
  • 无血清杜氏改良eagle′s培养基(DMEM),诱导星形胶质细胞分化

生化/生理作用

细胞通透性 cAMP 类似物,可激活 cAMP 依赖性蛋白激酶 (PKA)。

特点和优势

该化合物是环核苷酸研究的特色产品。点击此处 ,查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm

注意

在 pH 8.5 下会失去 2′-O-丁酰基

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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商品

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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