Merck

D0627

Sigma-Aldrich

N6,2′-O-二丁酰基腺苷 3′,5′-环单磷酸 钠盐

≥96% (HPLC), powder

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别名:
二丁酰 cAMP 钠盐, 二丁酰环磷腺苷 钠盐, 布拉地新 钠盐
线性分子式:
C18H23N5O8PNa
CAS号:
分子量:
491.37
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.51

生物来源

synthetic (organic)

质量水平

检测方案

≥96% (HPLC)

形式

powder

杂质

≤0.5% Cyclic AMP
≤3% monobutyryl derivatives

颜色

off-white

溶解性

H2O: 100 mg/mL

储存温度

−20°C

SMILES string

[Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC

InChI

1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1

InChI key

KRBZRVBLIUDQNG-JBVYASIDSA-M

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此商品
D0260C9630A9376
assay

≥96% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥93%

form

powder

form

powder

form

powder

form

powder

impurities

≤0.5% Cyclic AMP, ≤3% monobutyryl derivatives

impurities

≤0.5% cyclic AMP and 2′-O-monobutyryl-cyclic AMP, ≤3% N6-monobutyryl-cyclic AMP

impurities

-

impurities

-

color

off-white

color

white

color

-

color

-

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

water: 50 mg/mL, clear, colorless

solubility

water: 50 mg/mL, clear, colorless

应用

二丁酰基CAMP是一种可激活CAMP 依赖性蛋白激酶 (PKA)或CAMP/PKA信号传导途径的细胞可渗透型CAMP类似物。 二丁酰基CAMP可用作施万细胞等细胞的形态学分化诱导剂和细胞信号调节剂。 二丁酰基cAMP可用于多种分化研究,如神经元分化/神经分化。

生化/生理作用

细胞通透性 cAMP 类似物,可激活 cAMP 依赖性蛋白激酶 (PKA)。

注意

在 pH 8.5 下会失去 2′-O-丁酰基

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.

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