Merck
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D3321

Sigma-Aldrich

Dipeptidyl Peptidase VII human

recombinant, expressed in Sf9 cells

Synonym(s):
DPP7, Quiescent cell proline dipeptidase
Enzyme Commission number:
3.4.14.-
NACRES:
NA.54

重组

expressed in Sf9 cells

质量水平

200

形式

solution

specific activity

≥1,500 units/μg protein
≥1500 units/μg protein

分子量

89.1 kDa

相关疾病

diabetes; cardiovascular diseases

运输

dry ice

储存温度

−70°C

Related Categories

应用

Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes . DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research .

生化/生理作用

DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 . DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.

物理属性

Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa

单位定义

One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C

外形

Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol.

象形图

CorrosionHealth hazard

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

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