E1127

β-雌二醇17-(β-D-葡萄糖醛酸) 钠盐

• 别名: 1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide
• 线性分子式: C₂₄H₃₁O₈Na
• CAS号: 15087-02-2
• 分子量: 470.49
• MDL號碼: MFCD00056557
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24894388
• NACRES: NA.77

属性

• 無菌: non-sterile
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 溶解度: 0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: [Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O
• InChI: 1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;
• InChI 密鑰: GPLPNZUTAJWRLU-UHFFFAOYSA-N

说明

應用

β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay. It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).

生化／生理作用

Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332,H351
• 防範說明: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges