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Merck

E2127

Sigma-Aldrich

β-雌二醇3-(β-D-葡萄糖醛酸) 钠盐

别名:

1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide

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About This Item

线性分子式:
C24H31O8Na
CAS号:
分子量:
470.49
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

無菌

non-sterile

化驗

≥98% (HPLC)

形狀

powder

溶解度

water: 10 mg/mL, clear to slightly hazy

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[Na].CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(O)=O)ccc34)C1CCC2O

InChI

1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;

InChI 密鑰

JKYLXXZHJUQLMK-UHFFFAOYSA-N

應用

β-Estradiol 3-(β-D-glucuronide) sodium salt has been used in estrogen administration. It has also been used to determine the amount of two types of glucuronidated estradiols such as estradiol-3- α glucuronide and estradiol-17- β glucuronide.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Linda B Tabas et al.
Analytical biochemistry, 310(1), 61-66 (2002-11-05)
This study investigated a high-throughput assay to measure multidrug resistance-associated protein (MRP1)-mediated uptake into membrane vesicles. Typically, a rapid filtration technique using a 12-filter vacuum manifold is used. We report here the development of a 96-well microtiter dish assay. MRP1-transfected
Yuichiro Sato et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(9), 823-829 (2012-03-23)
The aims of this study were to quantify absolute protein levels of uridine 5'-diphosphate-glucuronosyltransferases (UGTs) 1A1 and 2B7 in human liver microsomes (HLMs) and to investigate their correlation with marker activities. A quantification method for UGT1A1 and UGT2B7 in HLMs
Direct, complex effects of estrogens on basal forebrain cholinergic neurons
Bora S H, et al.
Experimental Neurology, 194(2), 506-522 (2005)
B T Zhu et al.
Toxicology and applied pharmacology, 136(1), 186-193 (1996-01-01)
Estrogen-induced tumors in kidneys of male Syrian hamsters have been postulated to arise from cells which are damaged by free radicals and other reactive species generated during metabolic redox cycling of catecholestrogens and which at the same time are exposed
Matthew G Soars et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(6), 762-767 (2003-05-21)
Traditionally, the Michaelis-Menten equation has been used to determine kinetic parameters for in vitro glucuronidation assays. Recently, estradiol-3-glucuronide formation was shown to exhibit non-Michaelis-Menten kinetics consistent with autoactivation. A concern with the observation of nontraditional kinetics is that they may

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