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Merck

ED4SS

Sigma-Aldrich

乙二胺四乙酸 四钠盐 二水合物

99.0-102.0% (titration)

别名:

EDTA 四钠盐, 乙二胺四乙酸四钠盐 二水合物, 依地酸钙钠

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About This Item

线性分子式:
(NaOOCCH2)2NCH2CH2N(CH2COONa)2 · 2H2O
CAS号:
分子量:
416.20
Beilstein:
3861753
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

化驗

99.0-102.0% (titration)

形狀

crystalline

反應適用性

reagent type: chelator

溶解度

H2O: soluble, clear, colorless

SMILES 字串

O.O.[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.4Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;2*1H2/q;4*+1;;/p-4

InChI 密鑰

KSYNLCYTMRMCGG-UHFFFAOYSA-J

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一般說明

乙二胺四乙酸(EDTA)是一种多元酸,用作金属螯合剂。由4个羧基和2个氨基组成,孤对电子可螯合钙等多种金属离子。 

應用

乙二胺四乙酸四钠盐二水合物已用于:
  • 使股骨脱钙,用于骨软骨组织的组织处理和染色
  • 作为NH4Cl裂解缓冲液组分,用于红细胞裂解和整体鉴定
  • 分离小鼠结缔组织隐窝

生化/生理作用

乙二胺四乙酸(EDTA)可治疗重金属离子中毒患者。EDTA可抑制金属蛋白酶活性位点的锌离子,也可抑制其他金属离子依赖性蛋白酶,如钙依赖性半胱氨酸蛋白酶。EDTA可能会干扰金属依赖性生物学过程。EDTA可抑制血小板聚集,并且是血小板计数最常用的抗凝剂。EDTA可联合其他活性试剂抑制微生物和生物膜,例如柠檬酸、醇、抗生素、聚六亚甲基双胍(PHMB)季铵等消毒剂。EDTA可用作血液学检验的抗凝剂,稳定血细胞的细胞组分和形态。 
乙二胺四乙酸(EDTA)用于消除痕量重金属对酶的抑制作用,并抑制需要二价阳离子作为辅因子的酶。

訊號詞

Danger

危險分類

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2

標靶器官

Respiratory Tract

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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