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Merck
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F3917

Sigma-Aldrich

毛喉素

For use in molecular biology applications

别名:

7β-乙酰氧基-1α,6β,9α-二羟基-8,13-环氧-半日花-14-EN-11-酮, 洋紫苏醇, 考福新

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About This Item

经验公式（希尔记法）:
C22H34O7
CAS号:
66575-29-9
分子量:
410.50
Beilstein:
1692716
EC 号:
266-410-9
MDL编号:
MFCD00082317
UNSPSC代码:
12352200
PubChem化学物质编号:
24894799
NACRES:
NA.52

生物来源

Coleus forskohlii

描述

for activation of T cells

产品线

BioReagent

方案

≥98% (HPLC)

表单

powder

分子量

410.50  g/mol

颜色

white to off-white

溶解性

ethanol: soluble

适用性

suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells

储存温度

room temp

SMILES字符串

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

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一般描述

毛喉素是从Coleus forskohlii分离提取的细胞渗透双萜。

生化/生理作用

具有抗高血压、正性变力作用和腺苷酸环化酶活化特性的细胞通透性二萜类化合物。它的许多生物学作用是由于其对腺苷酸环化酶的激活以及由此而导致的细胞内cAMP浓度增加。毛喉素可影响钙电流并抑制MAP激酶。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H312

危险分类

Acute Tox. 4 Dermal

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000413823
0000413823
0000371987
0000371987
0000347265

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A Ramón-Cueto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(10), 3803-3815 (1998-06-06)
The lack of axonal regeneration in the injured adult mammalian spinal cord leads to permanent functional impairment. To induce axonal regeneration in the transected adult rat spinal cord, we have used the axonal growth-promoting properties of adult olfactory bulb ensheathing
Jin Wei Chung et al.
Biology of reproduction, 86(3), 80-80 (2011-12-03)
The signaling molecule DHH, secreted by Sertoli cells, has essential regulatory functions in testicular differentiation. DHH is required for the differentiation of peritubular myoid cells that line the seminiferous cords and steroidogenic Leydig cells. The testicular cords in Dhh-null male
T Marchetti et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 910-920 (2014-03-25)
Obstetric antiphospholipid syndrome (APS) is defined by pregnancy complications associated with antiphospholipid antibodies (aPL). The mechanisms of the pathogenic effects of aPL in pregnancy are poorly understood. Toll-like receptors (TLR) have been implicated previously in APS. The aims of our
Koji Yokoyama et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 302-314 (2014-10-11)
Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin-1β (IL-1β). However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore
Darren M Hutt et al.
Nature chemical biology, 6(1), 25-33 (2009-12-08)
Chemical modulation of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACi) is an increasingly important approach for modifying the etiology of human disease. Loss-of-function diseases arise as a consequence of protein misfolding and degradation, which lead to system failures. The
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