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生物来源
human pituitary glands
质量水平
无菌性
non-sterile
表单
powder
比活
~7,000 IU/mg (powder)
分子量
35 kDa
技术
cell culture | mammalian: suitable
杂质
HBsAg, HCV and HIV-1/HIV-2, tested negative
pH值（酸碱度）
7.4
溶解性
water: ~50 g/L
运输
ambient
储存温度
−20°C
基因信息
human ... FSHB(2488) , FSHR(2492)
一般描述
FSH的α链具有89个氨基酸而β链具有115个氨基酸。α 链是不具有活性的。FSH属于糖蛋白激素家族。它由垂体的促性腺激素细胞所分泌。
研究领域：细胞信号传导
研究领域：细胞信号传导
应用
来自人垂体的促卵泡激素（FSH）已被用于-
- 猕猴颗粒细胞的体外黄化
- B黄体细胞增殖检测
- 来自小鼠的腔前卵泡细胞的培养
- 未成熟卵丘卵母细胞复合物（COC）的体外熟化，来自小鼠和
- RAW264.7细胞系的培养物
生化/生理作用
α-链是不具有活性的；生物特异性是因为β-链。诱导卵巢格雷夫氏卵泡的成熟；促进男性生殖细胞的发育；激活胞质酪氨酸激酶。
FSH（促卵泡激素）可参与卵巢卵泡的生长和卵巢的甾类生成。FSHR（促卵泡激素受体）可在卵巢中与FSH相互作用并确定对此激素的反应性。FSHR水平降低会引起不良反应并影响卵泡生成。在高加索人群中，FSHR基因的某些多态性会在多囊卵巢综合征（PCOS）患者中更为常见。在男性胎儿和新生儿中，它可促进支持细胞的增殖。在青春期男性体内，它可以刺激精原细胞进行有丝分裂。FSH与受体FSH- r结合后正向调节G蛋白偶联受体/环磷酸腺苷（cAMP）/蛋白激酶A通路，以级联细胞内信号。
包装
包装尺寸基于蛋白质含量
其他说明
二链糖蛋白激素
质量
小管中还含有来自0.05 M pH 7.4磷酸缓冲液的0.1 mg盐。
抗体
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Karenne N Fru et al.
Biology of reproduction, 75(4), 568-574 (2006-07-14)
Ovulation and luteal formation in primates are associated with the sustained synthesis of progesterone. The observed high intrafollicular concentrations of progesterone during the periovulatory interval raise the possibility that this steroid serves as a precursor for mineralocorticoids. The aim of
J Wu et al.
Biology of reproduction, 63(1), 320-327 (2000-06-22)
Although it is known that LH receptors are present from the time of thecal differentiation, the role of LH during early follicle development is not yet clear. The effect of LH on preantral follicle development has therefore been investigated in
Y Figenschau et al.
Human reproduction (Oxford, England), 12(3), 523-531 (1997-03-01)
A simplified method for the preparation and long-term cultivation of granulosa-luteal cells in serum-free medium is described. The cells were harvested from women undergoing in-vitro fertilization, enriched by sedimentation and dissociated by enzymatic treatment. We demonstrated, by introducing a synthetic
Alfredo Ulloa-Aguirre et al.
Endocrinology, 159(8), 3020-3035 (2018-07-10)
FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role in the control of gonadal function and reproduction. Upon activation
Marina Grigorova et al.
The Journal of clinical endocrinology and metabolism, 96(9), E1534-E1541 (2011-07-08)
The detailed role of FSH in contributing to male testicular function and fertility has been debated. We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly
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