G11100P

Sigma-Aldrich

DMT-dG(ib) Pharmadite®

别名:
DMT-dG(ib) Phosphoramidite, N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Empirical Formula (Hill Notation):
C44H54N7O8P
CAS号:
分子量:
839.92
MDL number:
PubChem Substance ID:

Quality Level

biological source

non-animal source (no BSE/TSE risk)

type

for DNA synthesis

product line

Proligo Reagents

assay

≥99.5% (reversed phase HPLC)
>99.5% (31P-NMR)
conforms (1H-NMR)
conforms (LC/MS)

form

powder or granules

application(s)

oligo synthesis: suitable

impurities

>= 170ppm, none detected (S/N <2.5)
≤0.1% P(III) 100-169ppm (31P-NMR)
≤0.1% single unspecified Imprity (reversed phase HPLC)
≤0.3% dG2 (reversed phase HPLC, DMT-dG(ib) cyanoethyl-H-posphonate)
≤0.3% dG3 (reversed phase HPLC, DMT-dG(ib) phosphoramidate)
≤0.3% dG4 (reversed phase HPLC, DMT-dG(ib)-diisopropylamino-H-phosphonate)
≤0.30 wt. % water content (Karl Fischer)
≤0.5% P(V) -25-99ppm (31P-NMR)
≤3.0 wt. % residual solvent content

color

white to off-white

solubility

soluble, clear

nucleoside profile

base: deoxyguanosine
base protecting group: isobutyryl
2' protecting group: none
5' protecting group: DMT
deprotection: standard

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6

InChI

1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1

InChI key

FDRMKYVTIFSDPR-MMROLVBFSA-N

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Legal Information

Pharmadite is a registered trademark of Sigma-Aldrich Co. LLC

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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